Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNZA4L)

Drug Name

Griffithsin Drug Info

Synonyms

GRFT

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Phase 1	[1]
Severe acute respiratory syndrome (SARS)	1D65	Preclinical	[2]

Therapeutic Class

Antiviral Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Download the Complete Related Drug List

Drug(s) Targeting SARS-CoV spike glycoprotein (S)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID26911565-peptide-P9	DMUH012	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[3]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
SARS-CoV spike glycoprotein (S)	TTTL19V	SPIKE_CVHSA	Blocker	[2]

------------------------------------------------------------------------------------

References

1	ClinicalTrials.gov (NCT02875119) Study to Evaluate the Safety of Griffithsin in a Carrageenan Gel in Healthy Women
2	Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
3	A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses. Sci Rep. 2016 Feb 25;6:22008.