Details of the Drug

General Information of Drug (ID: DMO87PG)

• Drug Name: ISIS 140158

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Antisense drug
• Sequence: AACACAGAGGCGGCCCAGGA
• Cross-matching ID: TTD ID: D02YNE

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
SOAT2 messenger RNA (SOAT2 mRNA)	TTAK0IN	SOAT2_HUMAN	Not Available	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
SOAT2 messenger RNA (SOAT2 mRNA)	DTT	SOAT2	9.90E-02	-0.07	-0.27

References

• [1] US patent application no. 7,202,357, Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression.