Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTAK0IN)

DTT Name SOAT2 messenger RNA (SOAT2 mRNA)
Synonyms Sterol O-acyltransferase 2 (mRNA); Cholesterol acyltransferase 2 (mRNA); Acyl-coenzyme A:cholesterol acyltransferase 2 (mRNA); ACAT2 (mRNA); ACAT-2 (mRNA); ACACT2 (mRNA)
Gene Name SOAT2
DTT Type
Literature-reported target
 [1]
BioChemical Class
mRNA target
UniProt ID
SOAT2_HUMAN
TTD ID
T98315
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 2.3.1.26
Sequence
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQL
RELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHF
RTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLA
PYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFL
MKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKN
FAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLH
CWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARG
VAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTM
LFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
Function
Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
KEGG Pathway
Steroid biosynthesis (hsa00100 )
Reactome Pathway
LDL clearance (R-HSA-8964038 )
BioCyc Pathway
MetaCyc:HS09636-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
7 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 140148 DMKYWQ2 Discovery agent N.A. Investigative [1]
ISIS 140153 DMD60BA Discovery agent N.A. Investigative [1]
ISIS 140157 DMG2P7B Discovery agent N.A. Investigative [1]
ISIS 140158 DMO87PG Discovery agent N.A. Investigative [1]
ISIS 140161 DMRHSY6 Discovery agent N.A. Investigative [1]
Oleic acid anilide DMXCSVH Discovery agent N.A. Investigative [2]
PYRIPYROPENE A DMCTJAM Discovery agent N.A. Investigative [3]
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⏷ Show the Full List of 7 Investigative Drug(s)

Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTT
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Adrenocortical carcinoma 2C82 Kidney 9.90E-02 -0.07 -0.27
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References

1 US patent application no. 7,202,357, Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression.
2 Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5580-3.
3 Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors. Bioorg Med Chem Lett. 2005 Jan 17;15(2):385-8.