Details of the Drug

General Information of Drug (ID: DMOUT89)

Drug Name
Glutamic acid
Synonyms
D(-)-Glutamic acid; D-(-)-Glutamic acid; D-2-Aminoglutaric acid; D-2-Aminopentanedioic acid; D-Glutamicacid; D-Glutaminic acid; D-Glutaminsaeure; D-glutamate; D-glutamic acid; Gamma-D-Glutamic Acid; Glutamic acid D-form; Glutamic acid, D-; H-D-Glu-OH; L(+)-Glutamic acid; Lopac-G-2128; Q479989WEA; R-(-)-Glutamic acid; Tocris-0217; WHUUTDBJXJRKMK-GSVOUGTGSA-N; glutamate; (2R)-2-aminopentanedioic acid; (R)-2-aminopentanedioic acid; (r)-glutamic acid; 6893-26-1; CHEBI:15966; CHEMBL76232; D-Glu; DGL; MFCD00063112; UNII-Q479989WEA
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 147.13
Logarithm of the Partition Coefficient (xlogp) -3.7
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 5
ADMET Property
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 582.578 micromolar/kg/day [1]
Chemical Identifiers
Formula
C5H9NO4
IUPAC Name
(2R)-2-aminopentanedioic acid
Canonical SMILES
C(CC(=O)O)C(C(=O)O)N
InChI
WHUUTDBJXJRKMK-GSVOUGTGSA-N
InChIKey
1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
Cross-matching ID
PubChem CID
23327
ChEBI ID
CHEBI:15966
CAS Number
6893-26-1
DrugBank ID
DB02517
INTEDE ID
DR2511

Molecular Interaction Atlas of This Drug


Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
D-aspartate oxidase (DDO)
Main DME 		DE8PQ7T OXDD_HUMAN Substrate [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
2 Secreted d-aspartate oxidase functions in C. elegans reproduction and development. FEBS J. 2019 Jan;286(1):124-138.