Details of the Drug

General Information of Drug (ID: DMP2GN7)

• Drug Name: 4-aminobenzoic acid hydrazide
• Synonyms: 4-Aminobenzohydrazide; 5351-17-7; 4-Aminobenzhydrazide; 4-Aminobenzoic acid hydrazide; Amben hydrazide; p-Aminobenzhydrazide; Aminostimil; p-Aminobenzoic acid hydrazide; 4-Aminobenzoylhydrazine; p-Aminobenzoyl hydrazide; Benzoic acid, 4-amino-, hydrazide; p-Aminobenzoic hydrazide; p-Aminobenzoylhydrazine; para-Aminobenzhydrazide; NSC 640; BENZOIC ACID, p-AMINO-, HYDRAZIDE; EINECS 226-324-4; Myeloperoxidase Inhibitor-I; BRN 0639053; AI3-52435; CHEMBL2170241; (4-Aminobenzoyl)hydrazide, 95%; WPBZMCGPFHZRHJ-UHFFFAOYSA-N

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 151.17
  Logarithm of the Partition Coefficient (xlogp); -0.7
  Rotatable Bond Count (rotbonds); 1
  Hydrogen Bond Donor Count (hbonddonor); 3
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C7H9N3O
  IUPAC Name: 4-aminobenzohydrazide
  Canonical SMILES: C1=CC(=CC=C1C(=O)NN)N
  InChI: InChI=1S/C7H9N3O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,8-9H2,(H,10,11)
  InChIKey: WPBZMCGPFHZRHJ-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 21450
  CAS Number: 5351-17-7
  TTD ID: D05OZR

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Myeloperoxidase (MPO)	TTVCZPI	PERM_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Myeloperoxidase (MPO)	DTT	MPO	2.88E-01	-0.02	-0.16

References

• [1] Myeloperoxidase expression as a potential determinant of parthenolide-induced apoptosis in leukemia bulk and leukemia stem cells. J Pharmacol Exp Ther. 2010 Nov;335(2):389-400.