Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP2GN7)

Drug Name

4-aminobenzoic acid hydrazide Drug Info

Synonyms

4-Aminobenzohydrazide; 5351-17-7; 4-Aminobenzhydrazide; 4-Aminobenzoic acid hydrazide; Amben hydrazide; p-Aminobenzhydrazide; Aminostimil; p-Aminobenzoic acid hydrazide; 4-Aminobenzoylhydrazine; p-Aminobenzoyl hydrazide; Benzoic acid, 4-amino-, hydrazide; p-Aminobenzoic hydrazide; p-Aminobenzoylhydrazine; para-Aminobenzhydrazide; NSC 640; BENZOIC ACID, p-AMINO-, HYDRAZIDE; EINECS 226-324-4; Myeloperoxidase Inhibitor-I; BRN 0639053; AI3-52435; CHEMBL2170241; (4-Aminobenzoyl)hydrazide, 95%; WPBZMCGPFHZRHJ-UHFFFAOYSA-N

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 21450
CAS Number: CAS 5351-17-7
TTD Drug ID: DMP2GN7

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-101	DMM1YC4	Infectious disease	1A00-CA43.1	Phase 3	[2]
Mitiperstat	DM0BL2G	Heart failure with preserved ejection fraction	BD11.0	Phase 2/3	[3]
AZD-3241	DMANC59	Parkinson disease	8A00.0	Phase 2	[4]
AZD4831	DMRP3N8	Heart failure	BD10-BD13	Phase 1	[5]
AZD5904	DM8SCON	Chronic obstructive pulmonary disease	CA22	Discontinued in Phase 1	[6]
INV-311	DM8BZVI	Inflammation	1A00-CA43.1	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Myeloperoxidase (MPO)	TTVCZPI	PERM_HUMAN	Inhibitor	[1]

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References

1	Myeloperoxidase expression as a potential determinant of parthenolide-induced apoptosis in leukemia bulk and leukemia stem cells. J Pharmacol Exp Ther. 2010 Nov;335(2):389-400.
2	In vitro antibacterial activity of E-101 Solution, a novel myeloperoxidase-mediated antimicrobial, against Gram-positive and Gram-negative pathogens. J Antimicrob Chemother. 2011 Feb;66(2):335-42.
3	Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction. J Med Chem. 2022 Sep 8;65(17):11485-11496.
4	Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease. Brain. 2015 Sep;138(Pt 9):2687-700.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Clinical pipeline report, company report or official report of AstraZeneca (2009).
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2789).