Details of the Drug

General Information of Drug (ID: DMPT4WM)

• Drug Name: Cytosine Arabinose-5'-Phosphate
• Synonyms: 7075-11-8; Ara-5'-CMP; Ara-CMP; Cytarabine 5'-monophosphate; ((2R,3S,4S,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate; CYTOSINE ARABINOSE-5'-PHOSPHATE; AraCMP; Cytosine arabinoside monophosphate; Aracytidine 5'-phosphate; Cytosine arabinoside 5'MP; Aracytidine 5'-monophosphate; UNII-Y73692GHI4; Y73692GHI4; NSC 99445; 1-beta-D-Arabinofuranosylcytosine 5'-phosphate; Cytosine-beta-D-arabinofuranoside-5'-monophosphate; Cytosine beta-D-arabinofuranoside 5'-monophosphate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw); 323.2
  Logarithm of the Partition Coefficient (xlogp); -3.4
  Rotatable Bond Count (rotbonds); 4
  Hydrogen Bond Donor Count (hbonddonor); 5
  Hydrogen Bond Acceptor Count (hbondacc); 8
• Chemical Identifiers:
  Formula: C9H14N3O8P
  IUPAC Name: [(2R,3S,4S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
  Canonical SMILES: C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O
  InChI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7+,8-/m1/s1
  InChIKey: IERHLVCPSMICTF-CCXZUQQUSA-N
• Cross-matching ID:
  PubChem CID: 65177
  CAS Number: 7075-11-8
  DrugBank ID: DB02456
  TTD ID: D03SAZ

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Streptococcus Cytidylate kinase (Stre-coc cmk)	TTMFYEC	KCY_STRPN	Inhibitor	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.