Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTMFYEC)

DTT Name Streptococcus Cytidylate kinase (Stre-coc cmk)
Synonyms cmk; TIGR4; MssA protein; Cytidine monophosphate kinase; CMP kinase
Gene Name Stre-coc cmk
DTT Type
Literature-reported target
 [1]
BioChemical Class
Kinase
UniProt ID
KCY_STRPN
TTD ID
T84359
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 2.7.4.25
Sequence
MKTIQIAIDGPASSGKSTVAKIIAKDFGFTYLDTGAMYRAATYMALKNQLGVEEVEALLA
LLDQHPISFGRSETGDQLVFVGDVDITHPIRENEVTNHVSAIAAIPQVREKLVSLQQEIA
QQGGIVMDGRDIGTVVLPQAELKIFLVASVDERAERRYKENIAKGIETDLETLKKEIAAR
DYKDSHRETSPLKQAEDAVYLDTTGLNIQEVVEKIKAEAEKRM
Function Atp, datp, and gtp are equally effective as phosphate donors. Cmp and dcmp are the best phosphate acceptors.
KEGG Pathway
Pyrimidine metabolism (spn00240 )
Metabolic pathways (spn01100 )
BioCyc Pathway
SPNE170187:G1FZB-1624-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
4 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
2',3'-Dideoxycytidine-5'-Monophosphate DMCXR4M Discovery agent N.A. Investigative [1]
Cytidine-5'-Diphosphate DMA5FGS Discovery agent N.A. Investigative [1]
Cytidine-5'-Monophosphate DM6PAXD Discovery agent N.A. Investigative [2]
Cytosine Arabinose-5'-Phosphate DMPT4WM Discovery agent N.A. Investigative [1]
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References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.