Details of the Drug

General Information of Drug (ID: DMRCM7Q)

• Drug Name: 9-Phenyl-2,3-dihydro-1H-indeno[2,1-c]pyridine
• Synonyms: CHEMBL279297; 9-Phenyl-2,3-dihydro-1H-indeno[2,1-c]pyridine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 245.3
  Logarithm of the Partition Coefficient (xlogp); 2.4
  Rotatable Bond Count (rotbonds); 1
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 1
• Chemical Identifiers:
  Formula: C18H15N
  IUPAC Name: 9-phenyl-2,3-dihydro-1H-indeno[2,1-c]pyridine
  Canonical SMILES: C1C=C2C(=C(C3=CC=CC=C23)C4=CC=CC=C4)CN1
  InChI: InChI=1S/C18H15N/c1-2-6-13(7-3-1)18-16-9-5-4-8-14(16)15-10-11-19-12-17(15)18/h1-10,19H,11-12H2
  InChIKey: KIUIXTNMEMKNGK-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 15830914
  TTD ID: D05IHR

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H1 receptor (H1R)	TTTIBOJ	HRH1_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H1 receptor (H1R)	DTT	HRH1	6.74E-01	0.13	0.43

References

• [1] Conformationally-restricted ligands for the histamine H1 receptor. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1277-9.