Details of the Drug

General Information of Drug (ID: DMTHVQD)

Drug Name
RIPAZEPAM
Synonyms
RIPAZEPAM; Pyrazapon; 26308-28-1; CI-683; Ripazepam [USAN:INN]; Ripazepamum [INN-Latin]; CCRIS 552; UNII-92000WH9C9; Cl-683; BRN 0819726; CHEBI:82529; 92000WH9C9; 1-ethyl-3-methyl-8-phenyl-4,6-dihydropyrazolo[4,3-e][1,4]diazepin-5(1H)-one; 1-Ethyl-4,6-dihydro-3-methyl-8-phenylpyrazolo(4,3-e)(1,4)diazepin-5(1H)-one; 1-Ethyl-1,4,5,6-tetrahydro-3-methyl-8-phenylpyrazolo(4,3-e)(1,4)diazepin-5-on; C15H16N4O; Ripazepamum; Pyrazolo(4,3-e)(1,4)diazepin-5(1H)-one, 4,6-dihydro-1-ethyl-3-methyl-8-phenyl-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 268.31
Logarithm of the Partition Coefficient (xlogp) 1.8
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C15H16N4O
IUPAC Name
1-ethyl-3-methyl-8-phenyl-4,6-dihydropyrazolo[4,3-e][1,4]diazepin-5-one
Canonical SMILES
CCN1C2=C(C(=N1)C)NC(=O)CN=C2C3=CC=CC=C3
InChI
InChI=1S/C15H16N4O/c1-3-19-15-13(10(2)18-19)17-12(20)9-16-14(15)11-7-5-4-6-8-11/h4-8H,3,9H2,1-2H3,(H,17,20)
InChIKey
YFHYNLHGFKXAIQ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
33474
ChEBI ID
CHEMBL82529
CAS Number
26308-28-1
TTD ID
D03EQH
Drug Pharmacogenomic Perturbation (DPP)NEW Click to Jump to the Detailed DPP Information of This Drug
Drug ADMET Endpoint Profile (DAE)NEW Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor alpha-1 (GABRA1) TT1MPAY GBRA1_HUMAN Inhibitor [1]
Gamma-aminobutyric acid receptor (GAR) TTNJYV2 NOUNIPROTAC Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Synthesis and interaction of 5-(substituted-phenyl)-3-methyl-6,7-dihydropyrazolo[4,3-e] [1,4]diazepin-8(7H)-ones with benzodiazepine receptors in r... J Med Chem. 1985 May;28(5):683-5.