Details of the Drug

General Information of Drug (ID: DMTHWBI)

Drug Name

Nitrous oxide

Synonyms

Distickstoffmonoxid; Lachgas; Stickdioxyd; Dinitrogen monoxide; Dinitrogen oxide; Factitious air; Gaz hilarant; Hyponitrous acid anhydride; Laughing gas; Nitrogen hypoxide; Nitrogenium oxydulatum; Nitrous oxide [JAN]; Oxido nitroso; Oxido nitroso [Spanish]; Oxyde nitreux; Stickdioxyd [German]; N2O; Nitrous oxide [UN1070] [Nonflammable gas]; Diazyne 1-oxide; Gas, Laughing; NITROUS-OXIDE; Nitrogen oxide (N2O); Nitrous oxide (TN); Nitrous oxide [Anaesthetics, volatile]; Nitrous oxide, compressed; Nitrous oxide, refrigerated liquid; Nitrous oxide, refrigerated liquid [UN2201] [Nonflammable gas]; Oxide, Nitrous; Protoxyde d'azote; Protoxyde d'azote [French]; Nitrous oxide (JP15/USP); Oxidodinitrogen(N-N); Stickstoff(I)-oxid

Indication

Disease Entry	ICD 11	Status	REF
Anxiety disorder	6B00-6B0Z	Approved	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

44.013

Logarithm of the Partition Coefficient (xlogp)

0.5

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

Chemical Identifiers

Formula: N2O
IUPAC Name: nitrous oxide
Canonical SMILES: [N-]=[N+]=O
InChI: InChI=1S/N2O/c1-2-3
InChIKey: GQPLMRYTRLFLPF-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 948
ChEBI ID: CHEBI:17045
CAS Number: 10024-97-2
DrugBank ID: DB06690
TTD ID: D0O8DI

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
N-methyl-D-aspartate receptor (NMDAR)	TT9IK2Z	NOUNIPROTAC	Antagonist	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Ciliary neurotrophic factor (CNTF)	OTNEEWRN	CNTF_HUMAN	Gene/Protein Processing	[2]
Methionine synthase (MTR)	OTF2K2TA	METH_HUMAN	Gene/Protein Processing	[3]
Platelet-activating factor acetylhydrolase (PLA2G7)	OT6H6AMO	PAFA_HUMAN	Gene/Protein Processing	[4]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Anaesthetic drugs: linking molecular actions to clinical effects. Curr Pharm Des. 2006;12(28):3665-79.
2	Inducers of oxidative stress block ciliary neurotrophic factor activation of Jak/STAT signaling in neurons. J Neurochem. 2005 Mar;92(6):1521-30. doi: 10.1111/j.1471-4159.2004.02990.x.
3	Copper deficiency myelopathy and subacute combined degeneration of the cord - why is the phenotype so similar? Med Hypotheses. 2008 Aug;71(2):229-36.
4	Ambient air pollution and lipoprotein-associated phospholipase A? in survivors of myocardial infarction. Environ Health Perspect. 2011 Jul;119(7):921-6. doi: 10.1289/ehp.1002681. Epub 2011 Feb 28.