Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT9IK2Z)

• DTT Name: N-methyl-D-aspartate receptor (NMDAR)
• Synonyms: NMDA-R
• Gene Name: NO-GeName
• DTT Type: Successful target; [1]
• Related Disease:
  Acute pain [ICD-11: MG31]
  Alzheimer disease [ICD-11: 8A20]
  Anxiety disorder [ICD-11: 6B00-6B0Z]
  Bacterial infection [ICD-11: 1A00-1C4Z]
  Cerebral ischaemic stroke [ICD-11: 8B11]
  Corneal disease [ICD-11: 9A76-9A78]
  Epilepsy/seizure [ICD-11: 8A61-8A6Z]
  HIV-infected patients with tuberculosis [ICD-11: 1B10-1B14]
  Obesity [ICD-11: 5B80-5B81]
  Pain [ICD-11: MG30-MG3Z]
  Parkinsonism [ICD-11: 8A00]
  Schizophrenia [ICD-11: 6A20]
• UniProt ID: NOUNIPROTAC
• TTD ID: T69494

Molecular Interaction Atlas (MIA) of This DTT

12 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzphetamine	DMIJATC	Obesity	5B81	Approved	[2]
Cycloserine	DMT1I52	Bacterial infection	1A00-1C4Z	Approved	[3], [4]
Felbamate	DM1V5ZS	Epilepsy	8A60-8A68	Approved	[5], [6], [7]
Huperzine A	DMMAWLU	Alzheimer disease	8A20	Approved	[8]
Ketamine	DMT5HA4	Anaesthesia	9A78.6	Approved	[9], [10], [11]
L-glutamic acid	DM4PUDW	Schizophrenia	6A20	Approved	[1]
Levorphanol	DMGS80V	Pain	MG30-MG3Z	Approved	[12]
Magnesium	DMU4ORS	Ischemic stroke	8B11.5Z	Approved	[13]
Magnesium Sulfate	DMVEK07	Acute pain	MG31	Approved	[14]
Memantine	DMD9WSC	Alzheimer disease	8A20	Approved	[15], [16]
Nitrous oxide	DMTHWBI	Anxiety disorder	6B00-6B0Z	Approved	[17]
Orphenadrine	DMW542E	Parkinson disease	8A00.0	Approved	[18], [19]

28 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amitriptyline+ketamine	DMF50XJ	Neuropathic pain	8E43.0	Phase 3	[20]
AXS-05	DM6WZG8	Depression	6A70-6A7Z	Phase 3	[21]
Dexanabinol	DMRH291	Traumatic brain injury	NA07.Z	Phase 3	[22]
Esketamine	DMVU687	Depression	6A70-6A7Z	Phase 3	[23]
GLYX-13	DMOHUR2	Major depressive disorder	6A70.3	Phase 3	[23]
REL-1017	DM34GOF	Major depressive disorder	6A70.3	Phase 3	[24]
Remacemide	DM3YXP8	Pain	MG30-MG3Z	Phase 3	[10], [12]
NBTX-001	DM3MJUS	Post-traumatic stress disorder	6B40	Phase 2/3	[23]
AGN-241751	DM4KOAC	Major depressive disorder	6A70.3	Phase 2	[25]
Apimostinel	DM7IGO9	Major depressive disorder	6A70.3	Phase 2	[23]
AV-101	DMN7VK1	Major depressive disorder	6A70.3	Phase 2	[26]
CHF-3381	DMQ2O8V	Neuropathic pain	8E43.0	Phase 2	[20]
CNS-5161	DM16KJ3	Neuropathic pain	8E43.0	Phase 2	[20]
CP101	DM8X5Q1	Autism spectrum disorder	6A02	Phase 2	[27]
Dextromethorphan+quinidine	DMFI5J4	Diabetic neuropathy	8C0Z	Phase 2	[20]
Dimiracetam	DM96NHM	Neuropathic pain	8E43.0	Phase 2	[28]
MDL-27192	DM9FXU7	Epileptic seizures	8A61-8A6Z	Phase 2	[29], [16]
Neramexane	DM3ORVD	Cancer related pain	MG30	Phase 2	[30]
NYX-2925	DM1P60V	Fibromyalgia	MG30.01	Phase 2	[31]
NYX-2925	DMX04O8	Diabetic neuropathy	8C0Z	Phase 2	[32]
NYX-783	DMAVM2E	Post-traumatic stress disorder	6B40	Phase 2	[33]
SAGE-718	DM9RC7D	Parkinson disease	8A00.0	Phase 2	[34]
TRAXOPRODIL MESYLATE	DM1ZQEN	Neurological disorder	6B60	Phase 2	[35], [16]
ADCI	DM59EUY	Epileptic seizures	8A61-8A6Z	Phase 1	[36]
ASP-0777	DM8DBT6	Alzheimer disease	8A20	Phase 1	[37]
AZD6423	DMW4VQF	Suicidal ideation	MB26.A	Phase 1	[38]
BHV-5000	DMM2EZW	Rett syndrome	LD90.4	Phase 1	[31]
NBXT-001+Nobilis inhalation device	DMF3MN1	Alzheimer disease	8A20	Phase 1	[39]

24 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Midafotel	DM9FJ7N	Cognitive impairment	6D71	Discontinued in Phase 3	[40]
Selfotel	DM3FLIX	Cerebrovascular ischaemia	8B1Z	Discontinued in Phase 3	[12]
AZD6765	DMHZ3DE	Major depressive disorder	6A70.3	Discontinued in Phase 2	[41]
EAA-090	DMC28Y4	Diabetic neuropathy	8C0Z	Discontinued in Phase 2	[20]
SGS-111	DM6XJ9D	Cognitive impairment	6D71	Discontinued in Phase 2	[42]
CGP-37849	DMOULQ4	Neurological disorder	6B60	Discontinued in Phase 1	[43]
Delucemine	DMFUCZQ	Depression	6A70-6A7Z	Discontinued in Phase 1	[44]
S-1746	DMRXB8F	Cerebrovascular ischaemia	8B1Z	Discontinued in Phase 1	[45]
ACEA-1011	DMBY7AZ	Cerebral infarction	8B11.5Z	Terminated	[48]
ACEA-1031	DMCWNVB	Cerebrovascular ischaemia	8B1Z	Terminated	[49]
ACEA-1328	DMEH9OY	Cancer related pain	MG30	Terminated	[30]
ACEA-1416	DMRHSG4	Cerebrovascular ischaemia	8B1Z	Terminated	[50]
CNS-1531	DMZ5N2I	Nervous system disease	8A00-8E7Z	Terminated	[46]
CNS-5788	DMZY0SF	Cerebrovascular ischaemia	8B1Z	Terminated	[51]
FR-115427	DMY2IB8	Cerebrovascular ischaemia	8B1Z	Terminated	[52]
GPI-3000	DMBMAPH	Cerebrovascular ischaemia	8B1Z	Terminated	[53]
IDRA-21	DMG1FQW	Alzheimer disease	8A20	Terminated	[54]
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[55]
L-698544	DMLRBN1	Alzheimer disease	8A20	Terminated	[56]
LY-274614	DMG79NT	Dementia	6D80-6D86	Terminated	[57]
M-241247	DMIY51U	Cerebrovascular ischaemia	8B1Z	Terminated	[58]
NPS-1392	DMTWXE3	Cerebrovascular ischaemia	8B1Z	Terminated	[59]
PD-158473	DMS1XK5	Cerebrovascular ischaemia	8B1Z	Terminated	[60]
PD-159913	DMJ5STO	Cerebrovascular ischaemia	8B1Z	Terminated	[46]

3 Preclinical Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AD-529	DMBI1H2	Neuropathic pain	8E43.0	Preclinical	[46]
ADX-2 series	DM2WKDN	Schizophrenia	6A20	Preclinical	[47]
ED-1812	DMG4DHX	Pain	MG30-MG3Z	Preclinical	[46]

2 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ACPC	DMAZLWR	Neurological disorder	6B60	Investigative	[61], [16]
Aptiganel HCl	DMF1264	Ischemic stroke	8B11.5Z	Investigative	[12]

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