Details of the Drug

General Information of Drug (ID: DMTVY6K)

Drug Name

PGI-02749

Synonyms

PGI-02776; ZJ-11; ZJ-17; ZJ-43; NAAG peptidase inhibitors (brain injury, schizophrenia, pain); GCPII inhibitors (brain injury, schizophrenia, pain), PsychoGenics; Glutamate carboxypeptidase II inhibitors (brain injury, schizophrenia, pain), PsychoGenics; NAAG peptidase inhibitors (brain injury, schizophrenia, pain), PsychoGenics; N-acetylaspartylglutamate peptidase inhibitors (brain injury, schizophrenia, pain), PsychoGenics

Indication

Disease Entry	ICD 11	Status	REF
Brain injury	NA07.Z	Investigative	[1]
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Structure

3D Structure is Not Available

3D MOL

2D MOL

Cross-matching ID

TTD ID: D06LAX

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate carboxypeptidase II (GCPII)	TT9G4N0	FOLH1_HUMAN	Inhibitor	[1]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Brain injury

ICD Disease Classification

NA07.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glutamate carboxypeptidase II (GCPII)	DTT	FOLH1	1.40E-09	2.08	2.21

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1606).