Details of Disease

General Information of Disease (ID: DISZI5OZ)

• Disease Name: Brain injury
• Synonyms: brain trauma; brain Traumas; injury of brain; brain injury
• Disease Class: NA07: Intracranial injury
• Definition: Acute and chronic (see also brain INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and brain STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
• Disease Hierarchy:
  DISKB4RK: Injury
  DIS6ZC3X: Brain disease
  DIS1DVJH: Nervous system injury
  DISZI5OZ: Brain injury
• ICD Code:
  ICD-11: ICD-11: NA07.Z
  Expand ICD-11: 'NA07.Z

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ciclosporin	DMAZJFX	Approved	NA	[1]
Modafinil	DMYILBE	Approved	Small molecular drug	[2]

This Disease is Treated as An Indication in 5 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Xenon	DM1BHJD	Phase 3	NA	[3]
SLV-334	DMXCJKY	Phase 2	NA	[4]
VAS-203	DMKU93J	Phase 2	NA	[5]
Glial progenitor cell therapy	DM6HI3Q	Phase 1/2	NA	[6]
SNN-0031	DM2X3BR	Phase 1/2	NA	[7]

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
CM-GLP-1	DMH40I3	Discontinued in Phase 1/2	NA	[8]

This Disease is Treated as An Indication in 2 Preclinical Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ACT-N	DMKOTGG	Preclinical	NA	[9]
NN-818	DMLNYGX	Preclinical	NA	[10]

This Disease is Treated as An Indication in 15 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AMRS-001	DM3G165	Investigative	NA	[2]
C-10068	DMNV1ST	Investigative	NA	[11]
CNB-001	DMVC25M	Investigative	Small molecular drug	[2]
EU-C-001	DMR3487	Investigative	NA	[12]
Genetically modified allogeneic sertoli cells	DMW7Z75	Investigative	NA	[2]
IN-N01	DMI5N23	Investigative	Antibody	[13]
Metallothionein	DM7C7ZF	Investigative	NA	[2]
NanoDisks	DMSSHII	Investigative	NA	[2]
NK-101	DM0KRR4	Investigative	NA	[2]
NP93-31	DMMZXRT	Investigative	NA	[14]
PGI-02749	DMTVY6K	Investigative	NA	[15]
Phylomers	DMU30IO	Investigative	Small molecular drug	[16]
RTL-551	DMOC9G6	Investigative	NA	[2]
TL-14077	DM2P6BP	Investigative	NA	[2]
TRP6-01	DMC5KVP	Investigative	NA	[2]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] ClinicalTrials.gov (NCT00332462) A Study to Evaluate the Efficiency of Intravenously Administered Cyclosporine in de Novo Liver Transplant Recipients. U.S. National Institutes of Health.
• [2] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans. Life Sci. 2012 Oct 15;91(13-14):743-8.
• [5] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023224)
• [6] ClinicalTrials.gov (NCT02478450) Study to Investigate the Safety of the Transplantation (by Injection) of Human Glial Restricted Progenitor Cells (hGRPs; Q-Cells) Into Subjects With AmyotrophicLateral Sclerosis (ALS).
• [7] ClinicalTrials.gov (NCT02408562) Study on Tolerability of Repeat i.c.v. Administration of sNN0031 Infusion Solution in Patients With PD. U.S. National Institutes of Health.
• [8] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023519)
• [9] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019288)
• [10] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020811)
• [11] Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
• [12] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 360).
• [13] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402).
• [14] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457).
• [15] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1606).
• [16] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2773).