Details of the Drug

General Information of Drug (ID: DMU36HT)

• Drug Name: Alpha-D-Glucose-1-Phosphate
• Synonyms: beta-D-Glucose 1-phosphate; 1-O-phosphono-beta-D-glucopyranose; 1-phospho-beta-D-glucopyranose; CHEBI:16218; beta-glucose-1-phosphate; UNII-X9QC3WD5G5; X9QC3WD5G5; beta-D-glucopyranose 1-(dihydrogen phosphate); 1-o-phosphono-; A-d-glucopyranose; Dol-P-glc; XGP; Glucosylphosphodolichol; Dolichylglucose phosphate; Epitope ID:145000; AC1L3U9A; AC1Q6S5M; NCIStruc2_000464; NCIStruc1_000461; SCHEMBL361623; CHEMBL67622; beta-d-glucopyranosyl phosphate; dolichol-D-glucosylmonophosphate; .alpha.-D-Glucose, 1-phosphate; ZINC3953999

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 2:
  Molecular Weight (mw); 260.14
  Logarithm of the Partition Coefficient (xlogp); -3.8
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 6
  Hydrogen Bond Acceptor Count (hbondacc); 9
• Chemical Identifiers:
  Formula: C6H13O9P
  IUPAC Name: [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dihydrogen phosphate
  Canonical SMILES: C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)OP(=O)(O)O)O)O)O)O
  InChI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5-,6-/m1/s1
  InChIKey: HXXFSFRBOHSIMQ-VFUOTHLCSA-N
• Cross-matching ID:
  PubChem CID: 65533
  ChEBI ID: CHEBI:29042
  CAS Number: 59-56-3
  DrugBank ID: DB02843
  TTD ID: D0S5WE

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycogen phosphorylase muscle form (GP)	TTZHY6R	PYGM_HUMAN	Inhibitor	[1]
Pseudomonas Phosphomannomutase/phosphoglucomutase (Pseudo algC)	TTLP3GX	ALGC_PSEAE	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glycogen phosphorylase muscle form (GP)	DTT	PYGM	2.69E-01	-0.23	-0.14

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.