Details of the Drug

General Information of Drug (ID: DMU5EVR)

Drug Name
GSK2586881
Synonyms GSK-2586881
Indication
Disease Entry ICD 11 Status REF
Acute lung injury NB32.3 Phase 2 [1]
Pulmonary arterial hypertension BB01.0 Phase 1 [2]
Cross-matching ID
TTD ID
D0ET2T
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin-converting enzyme 2 (ACE2) TTUI5H7 ACE2_HUMAN Modulator [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Acute lung injury
ICD Disease Classification NB32.3
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Angiotensin-converting enzyme 2 (ACE2) DTT ACE2 3.93E-02 0.4 1.1
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT01597635) The Safety, Tolerability, PK and PD of GSK2586881 in Patients With Acute Lung Injury. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 New Developments in the Pharmacological Treatment of Hypertension: Dead-End or a Glimmer at the Horizon . Curr Hypertens Rep. 2015; 17(6): 42.