Details of the Drug

General Information of Drug (ID: DMUES7Y)

Drug Name

AB154

Synonyms

Domvanalimab

Indication

Disease Entry	ICD 11	Status	REF
Non-small-cell lung cancer	2C25	Phase 3	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
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Drug Type

Antibody

Cross-matching ID

Repurposed Drugs (RPD)

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
V-set and immunoglobulin domain-containing protein 9 (TIGIT)	TTWNL74	TIGIT_HUMAN	Inhibitor	[3]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT04736173) Study to Evaluate Monotherapy Compared to Combination Immunotherapies in Participants With PD-L1 Positive Non-small Cell Lung Cancer. U.S. National Institutes of Health.
2	ClinicalTrials.gov (NCT03628677) A Study to Evaluate the Safety and Tolerability of AB154 in Participants With Advanced Malignancies. U.S. National Institutes of Health.
3	Clinical pipeline report, company report or official report of Arcus Biosciences.