Details of the Drug

General Information of Drug (ID: DMUNBMA)

Drug Name
MT-1621
Indication
Disease Entry ICD 11 Status REF
Thymidine kinase 2 deficiency 5C55.1 Phase 3 [1]
Drug Type
Deoxynucleoside
Cross-matching ID
TTD ID
DI4SM3

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thymidine kinase 2 (Mt-TK2) TT7KNZQ KITM_HUMAN Replacement [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT04581733) A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of Modis Therapeutics.
3 N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem. 2006 Dec 28;49(26):7766-73.