Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT7KNZQ)

DTT Name Thymidine kinase 2 (Mt-TK2)
Synonyms dnk; Multispecific deoxynucleoside kinase; Dm-Dnk; Deoxyribonucleoside kinase
Gene Name dnk
DTT Type
Clinical trial target
 [1]
Related Disease
Inborn purine/pyrimidine/nucleotide metabolism error [ICD-11: 5C55]
BioChemical Class
Kinase
UniProt ID
KITM_HUMAN
TTD ID
T22976
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 2.7.1.21
Sequence
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIA
SGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDR
HTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIV
YLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHH
MERMLELFEQNRDRILTPENRKHCP
Function
Deoxyribonucleoside kinase that has a broad specificity phosphorylating thymidine, deoxyadenosine, deoxycytidine and deoxyguanosine. Specificity is higher for pyrimidine nucleosides. Several anti-viral and anti-cancer nucleoside analogs are also efficiently phosphorylated.
KEGG Pathway
Pyrimidine metabolism (hsa00240 )
Drug metabolism - other enzymes (hsa00983 )
Metabolic pathways (hsa01100 )
Nucleotide metabolism (hsa01232 )
Reactome Pathway
Pyrimidine salvage (R-HSA-73614 )
BioCyc Pathway
MetaCyc:HS09420-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
MT-1621 DMUNBMA Thymidine kinase 2 deficiency 5C55.1 Phase 3 [2]
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3 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine DMU3VWA Discovery agent N.A. Investigative [1]
1-[5-(triphenylmethoxy)pentyl]thymine DMFHBJM Discovery agent N.A. Investigative [1]
1-[6-(triphenylmethoxy)hexyl]thymine DM5NVHO Discovery agent N.A. Investigative [1]
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References

1 N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem. 2006 Dec 28;49(26):7766-73.
2 Clinical pipeline report, company report or official report of Modis Therapeutics.