Details of the Drug

General Information of Drug (ID: DMVA186)

Drug Name

R7334

Synonyms

R 7334; 2-Nitro-6,7,8,9-tetrahydronaphtho(1,2-b)furan; 2-nitro-6,7,8,9-tetrahydrobenzo[g][1]benzofuran; 6,7,8,9-Tetrahydro-2-nitronaphtho(1,2-b)furan

Indication

Disease Entry	ICD 11	Status	REF
Macular degeneration	9B78.3	Phase 1	[1]
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Drug Type

Antibody

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 1

Molecular Weight (mw)

346.2

Logarithm of the Partition Coefficient (xlogp)

5.4

Rotatable Bond Count (rotbonds)

2

Hydrogen Bond Donor Count (hbonddonor)

1

Hydrogen Bond Acceptor Count (hbondacc)

3

Chemical Identifiers

Formula: C18H13Cl2NO2
IUPAC Name: 7-chloro-2-(4-chlorophenyl)-3,8-dimethylquinoline-4-carboxylic acid
Canonical SMILES: CC1=C(C=CC2=C1N=C(C(=C2C(=O)O)C)C3=CC=C(C=C3)Cl)Cl
InChI: InChI=1S/C18H13Cl2NO2/c1-9-14(20)8-7-13-15(18(22)23)10(2)16(21-17(9)13)11-3-5-12(19)6-4-11/h3-8H,1-2H3,(H,22,23)
InChIKey: VMKRTBNGLFHQNX-UHFFFAOYSA-N

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Macular degeneration

ICD Disease Classification

9B78.3

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Placenta growth factor (PlGF)	DTT	PGF	1.44E-03	-0.32	-1.84

Molecular Expression Atlas (MEA)

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References

1	ClinicalTrials.gov (NCT00702494) Phase I Study on Monoclonal Antibody TB-403 Directed Against PlGF in Patients With Solid Tumours. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Roche (2009).