Details of the Drug

General Information of Drug (ID: DMVYALJ)

• Drug Name: 4-(2,5-Diphenyl-furan-3-yl)-morpholine
• Synonyms: CHEMBL323451; 4-(2,5-Diphenyl-furan-3-yl)-morpholine; 2,5-Diphenyl-3-morpholinofuran

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 305.4
  Logarithm of the Partition Coefficient (xlogp); 4.1
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 0
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C20H19NO2
  IUPAC Name: 4-(2,5-diphenylfuran-3-yl)morpholine
  Canonical SMILES: C1COCCN1C2=C(OC(=C2)C3=CC=CC=C3)C4=CC=CC=C4
  InChI: InChI=1S/C20H19NO2/c1-3-7-16(8-4-1)19-15-18(21-11-13-22-14-12-21)20(23-19)17-9-5-2-6-10-17/h1-10,15H,11-14H2
  InChIKey: UIZBMSXOYPJXSV-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 10990391
  TTD ID: D0J4AT

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 4A (PDE4A)	TTZ97H5	PDE4A_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Phosphodiesterase 4A (PDE4A)	DTT	PDE4A	9.26E-01	-3.01E-03	-0.01

References

• [1] Substituted furans as inhibitors of the PDE4 enzyme. Bioorg Med Chem Lett. 1999 Feb 8;9(3):323-6.