Details of the Drug

General Information of Drug (ID: DMWFI4A)

• Drug Name: CP-67015
• Synonyms: 100325-51-7; CCRIS 2955; CP-67015; CP 67015; CP-67,015; 3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-4-oxo-7-(4-pyridinyl)-; 3-Quinolinecarboxylicacid, 1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-7-(4-pyridinyl)-; ACMC-20m3dd; AC1L2S7K; SCHEMBL9304919; CTK0H9319; DTXSID00143163; AKOS030543955; LS-141575; 1-ethyl-6,8-difluoro-4-oxo-7-pyridin-4-ylquinoline-3-carboxylic acid; 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-7-(4-pyridinyl)-; 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dih

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Terminated	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 330.28
  Logarithm of the Partition Coefficient (xlogp); 2.2
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 7
• Chemical Identifiers:
  Formula: C17H12F2N2O3
  IUPAC Name: 1-ethyl-6,8-difluoro-4-oxo-7-pyridin-4-ylquinoline-3-carboxylic acid
  Canonical SMILES: CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)C3=CC=NC=C3)F)C(=O)O
  InChI: InChI=1S/C17H12F2N2O3/c1-2-21-8-11(17(23)24)16(22)10-7-12(18)13(14(19)15(10)21)9-3-5-20-6-4-9/h3-8H,2H2,1H3,(H,23,24)
  InChIKey: AVTJRMCCKOBMQP-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 127557
  CAS Number: 100325-51-7
  TTD ID: D03YLN

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial DNA gyrase (Bact gyrase)	TTN6J5F	GYRA_STAAU ; GYRB_STAAU	Modulator	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003590)
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.