Details of the Drug

General Information of Drug (ID: DMX4IS3)

• Drug Name: Mephenoxalone
• Synonyms: 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one; 5-(o-Methoxyphenoxymethyl)-2-oxazolidinone; 5-(o-Methoxyphenoxymethyl)-2-oxazolidone; AHR 233; Alkapol peg-400; CL 27,319; Control-OM; Dorsiflex; Dorsilon; EINECS 200-723-3; Ekilan; Lenetran; Lenetran TAB; Lenetranat; MEPHENOXALONE; Mefenoxalona; Mefenoxalona [INN-Spanish]; Mefenoxalone; Mephenoxalone [INN:DCF]; Mephenoxalonum [INN-Latin]; Methoxadone; Methoxydon; Methoxydon(E); Methoxydone; Metoxadone; Moderamin; Placidex; Riself; Transpoise; Trepidone; Valanas; Xerene
• Therapeutic Class: Anxiolytic Agents
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight; 223.228
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 4
  Hydrogen Bond Donor Count; 1
  Hydrogen Bond Acceptor Count; 4
• Chemical Identifiers:
  Formula: C11H13NO4
  IUPAC Name: 5-[(2-methoxyphenoxy)methyl]-1,3-oxazolidin-2-one
  Canonical SMILES: COC1=CC=CC=C1OCC2CNC(=O)O2
  InChI: InChI=1S/C11H13NO4/c1-14-9-4-2-3-5-10(9)15-7-8-6-12-11(13)16-8/h2-5,8H,6-7H2,1H3,(H,12,13)
  InChIKey: ZMNSRFNUONFLSP-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 6257
  ChEBI ID: CHEBI:134916
  CAS Number: 70-07-5
  DrugBank ID: DB13754
  VARIDT ID: DR01223

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug and toxin extrusion protein 1 (SLC47A1)	DTZGT0P	S47A1_HUMAN	Substrate	[1]

References

• [1] Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1). J Pharmacol Exp Ther. 2010 Sep 1;334(3):936-44.