Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX4IS3)

Drug Name
Mephenoxalone Drug Info
Synonyms
5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one; 5-(o-Methoxyphenoxymethyl)-2-oxazolidinone; 5-(o-Methoxyphenoxymethyl)-2-oxazolidone; AHR 233; Alkapol peg-400; CL 27,319; Control-OM; Dorsiflex; Dorsilon; EINECS 200-723-3; Ekilan; Lenetran; Lenetran TAB; Lenetranat; MEPHENOXALONE; Mefenoxalona; Mefenoxalona [INN-Spanish]; Mefenoxalone; Mephenoxalone [INN:DCF]; Mephenoxalonum [INN-Latin]; Methoxadone; Methoxydon; Methoxydon(E); Methoxydone; Metoxadone; Moderamin; Placidex; Riself; Transpoise; Trepidone; Valanas; Xerene
Therapeutic Class
Anxiolytic Agents
Cross-matching ID
PubChem CID
6257
ChEBI ID
CHEBI:134916
CAS Number
CAS 70-07-5
TTD Drug ID
DMX4IS3
VARIDT Drug ID
DR01223

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTP
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Transported By Multidrug and toxin extrusion protein 1 (SLC47A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aciclovir DMYLOVR Genital herpes 1A94 Approved [2]
Metformin DM89QE1 Colorectal carcinoma Approved [3]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [2]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [2]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [4]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [2]
Topotecan DMP6G8T Central nervous system neoplasm Approved [2]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [5]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [6]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [7]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug and toxin extrusion protein 1 (SLC47A1) DTZGT0P S47A1_HUMAN Substrate [1]

References

1 Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1). J Pharmacol Exp Ther. 2010 Sep 1;334(3):936-44.
2 Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71.
3 Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms. Am J Physiol Renal Physiol. 2010 Apr;298(4):F997-F1005.
4 Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine. Antimicrob Agents Chemother. 2011 Jul;55(7):3091-8.
5 Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice. J Pharmacol Exp Ther. 2010 Aug;334(2):651-6.
6 Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195.
7 FDA Drug Development and Drug Interactions