Details of the Drug

General Information of Drug (ID: DMY60DT)

Drug Name
N8-GP
Synonyms NN7088
Indication
Disease Entry ICD 11 Status REF
Factor VIII deficiency 3B10 Phase 3 [1]
Cross-matching ID
TTD ID
D00UUL

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Coagulation factor VIII (F8) TT1290U FA8_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Factor VIII deficiency
ICD Disease Classification 3B10
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Coagulation factor VIII (F8) DTT F8 1.08E-22 0.89 1.82
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT02137850) Safety and Efficacy of Turoctocog Alfa Pegol (N8-GP) in Previously Untreated Patients With Haemophilia A. U.S. National Institutes of Health.
2 Enhancing the pharmacokinetic properties of recombinant factor VIII: first-in-human trial of glycoPEGylated recombinant factor VIII in patients with hemophilia A. J Thromb Haemost. 2013 Apr;11(4):670-8.