Details of Disease

Disease Name

Factor VIII deficiency

Disease Class

3B10: Coagulation defect

Disease Hierarchy

DIS01GPL: Grass pollen hypersensitivity

DISQNVDZ: Factor VIII deficiency

ICD-11

ICD-11: 3B10

ICD-10

ICD-10: D66

Expand ICD-11

'3B10.Z

Disease Identifiers

MESH ID

D006467

OMIM ID

134500

MedGen ID

488140

SNOMED CT ID

234440005

General Information of Disease (ID: DISQNVDZ)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Emicizumab	DM0AQ83	Approved	Antibody	[1]
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This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
N8-GP	DMY60DT	Phase 3	NA	[2]
OBI-1	DMENDP6	Phase 3	NA	[3]
Plasma derived factor VIII PEGylated liposomal	DM1RWMY	Phase 3	NA	[4]
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This Disease is Treated as An Indication in 5 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Human recombinant factor VIII	DMG1BYH	Investigative	NA	[5]
IATX-FVIII	DM8U4HE	Investigative	NA	[5]
LA-N8	DMLGK27	Investigative	NA	[5]
LG-888	DM1W8Y0	Investigative	NA	[5]
LG-889	DMIHDEB	Investigative	NA	[5]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

References

1	2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
2	ClinicalTrials.gov (NCT02137850) Safety and Efficacy of Turoctocog Alfa Pegol (N8-GP) in Previously Untreated Patients With Haemophilia A. U.S. National Institutes of Health.
3	ClinicalTrials.gov (NCT01434511) Study of Modified Recombinant Factor VIII (OBI-1) in Subjects With Congenital Hemophilia A. U.S. National Institutes of Health.
4	Recombinant factor VIII in the management of hemophilia A: current use and future promise. Ther Clin Risk Manag. 2009; 5: 391-402.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607).