Details of the Drug

General Information of Drug (ID: DMYJ1ZB)

Drug Name
HN-10200
Indication
Disease Entry ICD 11 Status REF
Cardiac failure BD10-BD13 Discontinued in Phase 2 [1]
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 293.4
Logarithm of the Partition Coefficient (xlogp) 1.2
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C12H11N3O2S2
IUPAC Name
2-(3-methoxy-4-methylsulfinylthiophen-2-yl)-1H-imidazo[4,5-b]pyridine
Canonical SMILES
COC1=C(SC=C1S(=O)C)C2=NC3=C(N2)C=CC=N3
InChI
InChI=1S/C12H11N3O2S2/c1-17-9-8(19(2)16)6-18-10(9)12-14-7-4-3-5-13-11(7)15-12/h3-6H,1-2H3,(H,13,14,15)
InChIKey
WUXLGRPRVSOZPL-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
101656410
TTD ID
D0C1TJ

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Phosphodiesterase (PDE) TTUST1O NOUNIPROTAC Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001592)
2 HN-10200 causes endothelium-independent relaxations in isolated canine arteries. Cardiovasc Drugs Ther. 1992 Apr;6(2):159-65.