Details of the Drug

General Information of Drug (ID: DMZVEN0)

Drug Name

GSK3965193

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis B	1E51	Phase 1	[1]
------------------------------------------------------------------------------------

Drug Type

Small molecule

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Terminal nucleotidyltransferase 4A (TENT4A)	TT0XZ4Q	PAPD7_HUMAN	Inhibitor	[2]
Terminal nucleotidyltransferase 4B (TENT4B)	TTB5R6M	PAPD5_HUMAN	Inhibitor	[2]

------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT05330455) Four-part, Randomized, Double-blind (Parts 1, 2A, 3 and 4), Multi-center, Placebo-controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK3965193 Monotherapy in Healthy Participants and in Participants Living With Chronic Hepatitis B Infection; and GSK3965193 in Combination With Bepirovirsen in Participants Living With Chronic Hepatitis B Infection. U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of GlaxoSmithKline