Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT582KR)

DTP Name Multidrug resistance-associated protein 6 (ABCC6)
Gene Name ABCC6
UniProt ID
O95255 (MRP6_HUMAN)
VARIDT ID
DTD0017
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms
ABC34; ABCC6; ARA; ATP-binding cassette sub-family C member 6; Anthracycline resistance-associated protein; EST349056; GACI2; MLP1; MOAT-E; MOATE; MRP6; Multi-specific organic anion transporter E; PXE; PXE1; URG7
DTP Family ATP-Binding Cassette (ABC) Superfamily
Drug Conjugate Transporter (DCT) Family (ABCC)
Tissue Specificity Expressed in kidney and liver. Very lowexpression in other tissues.
Sequence
MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGR
GYLRMSPLFKAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVF
LIHTERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQ
FVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLG
RENSSEELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLL
KAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSA
CLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRL
TESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQ
MRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQ
VSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDR
LVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLA
VVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPP
WLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPL
AALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQEL
LQRKGALMCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRT
TSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVA
SFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLL
FQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVV
AVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAF
RTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAG
LVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWP
QGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAE
GGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQL
KALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM
QAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQES
GLV
Function
This transporter may participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).
Endogenous Substrate(s) DNP; Glutathione conjugates; N-ethylmaleimide S-glutathione; Organoanions; Leukotriene C4
TCDB ID
3.A.1.208.10
Gene ID
368
KEGG Pathway
ABC transporters (hsa02010 )
Reactome Pathway
Defective ABCC6 causes PXE (R-HSA-5690338 )
ABC-family proteins mediated transport (R-HSA-382556 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
3 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzbromarone DMC3YUA Gout FA25 Approved [1]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [2]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [2]
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1 Preclinical Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epipodophyllotoxins DMVNR20 N. A. N. A. Preclinical [2]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 2.23E-01 -7.04E-02 -3.21E-01
Adrenocortical carcinoma 2D11.Z Kidney 2.54E-01 -1.83E-01 -4.33E-01
Alopecia ED70 Skin from scalp 8.94E-03 1.89E-01 6.53E-01
Alzheimer's disease 8A20 Entorhinal cortex 8.47E-01 -1.50E-02 -1.06E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 7.25E-01 -4.60E-02 -1.89E-01
Aortic stenosis BB70 Calcified aortic valve 9.93E-01 -4.81E-02 -1.26E-01
Apnea 7A40 Hyperplastic tonsil 5.45E-02 -1.59E-01 -1.46E+00
Arthropathy FA00-FA5Z Peripheral blood 2.41E-02 1.27E-01 6.49E-01
Asthma CA23 Nasal and bronchial airway 5.60E-03 -1.04E-01 -1.27E-01
Atopic dermatitis EA80 Skin 5.02E-01 -3.34E-02 -1.56E-01
Autism 6A02 Whole blood 5.48E-01 4.72E-02 2.48E-01
Autoimmune uveitis 9A96 Peripheral monocyte 4.16E-01 1.87E-01 5.67E-01
Autosomal dominant monocytopenia 4B04 Whole blood 2.79E-01 -2.52E-01 -1.08E+00
Bacterial infection of gingival 1C1H Gingival tissue 2.82E-01 3.53E-02 1.83E-01
Batten disease 5C56.1 Whole blood 5.08E-01 2.68E-01 7.49E-01
Behcet's disease 4A62 Peripheral blood 3.38E-01 9.59E-02 6.46E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 8.48E-01 1.38E-02 7.80E-02
Bladder cancer 2C94 Bladder tissue 1.21E-01 1.72E-01 6.79E-01
Breast cancer 2C60-2C6Z Breast tissue 6.07E-37 -6.18E-01 -9.18E-01
Cardioembolic stroke 8B11.20 Whole blood 9.84E-04 3.10E-01 1.03E+00
Cervical cancer 2C77 Cervical tissue 5.91E-01 -1.97E-02 -8.84E-02
Childhood onset rheumatic disease FA20.Z Peripheral blood 5.39E-01 -2.14E-02 -9.25E-02
Chronic hepatitis C 1E51.1 Whole blood 2.14E-01 1.04E-01 7.21E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 1.88E-01 -7.29E-02 -2.03E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 5.30E-01 3.86E-02 8.44E-02
Chronic rhinosinusitis CA0A Sinus mucosa tissue 8.50E-02 -2.03E-01 -7.65E-01
Colon cancer 2B90 Colon tissue 9.82E-21 -3.51E-01 -9.78E-01
Coronary artery disease BA80-BA8Z Peripheral blood 8.76E-01 2.99E-02 1.78E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 5.30E-01 -1.34E-02 -1.69E-01
Endometriosis GA10 Endometrium tissue 1.23E-01 -4.35E-02 -1.90E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 5.55E-01 -8.05E-02 -6.52E-01
Familial hypercholesterolemia 5C80.00 Whole blood 7.78E-02 1.34E-01 6.27E-01
Gastric cancer 2B72 Gastric tissue 6.72E-01 -3.43E-02 -1.29E-01
Glioblastopma 2A00.00 Nervous tissue 6.28E-15 9.48E-02 4.71E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 3.54E-03 -4.60E-01 -1.78E+00
Head and neck cancer 2D42 Head and neck tissue 2.72E-12 -2.56E-01 -2.52E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 8.61E-01 -2.01E-02 -1.84E-01
Huntington's disease 8A01.10 Whole blood 2.12E-02 1.73E-01 1.50E+00
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 8.16E-03 3.35E-01 1.73E+00
Immunodeficiency 4A00-4A20 Peripheral blood 1.10E-02 9.30E-02 1.60E+00
Influenza 1.00E+30 Whole blood 6.74E-01 1.50E-02 2.04E-01
Interstitial cystitis GC00.3 Bladder tissue 9.23E-01 6.59E-02 2.56E-01
Intracranial aneurysm 8B01.0 Intracranial artery 5.70E-02 -1.34E-01 -4.61E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 4.12E-02 -1.57E-01 -3.96E-01
Ischemic stroke 8B11 Peripheral blood 6.80E-01 -4.12E-02 -1.64E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 2.05E-01 -9.41E-02 -2.94E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 7.79E-02 2.82E-01 1.22E+00
Lateral sclerosis 8B60.4 Skin 5.13E-01 5.03E-02 4.48E-01
Liver cancer 2C12.0 Liver tissue 4.25E-13 -6.31E-01 -1.17E+00
Liver failure DB99.7-DB99.8 Liver tissue 1.75E-04 -2.80E+00 -6.05E+00
Lung cancer 2C25 Lung tissue 2.81E-44 -5.94E-01 -1.82E+00
Lupus erythematosus 4A40 Whole blood 7.37E-01 -1.41E-02 -6.62E-02
Major depressive disorder 6A70-6A7Z Whole blood 8.63E-02 5.93E-02 2.18E-01
Major depressive disorder 6A70-6A7Z Hippocampus 6.00E-01 6.78E-02 3.96E-01
Melanoma 2C30 Skin 3.39E-04 -3.30E-01 -8.81E-01
Multiple myeloma 2A83.1 Bone marrow 7.09E-03 -2.26E-01 -1.51E+00
Multiple myeloma 2A83.1 Peripheral blood 6.06E-01 -1.02E-02 -5.72E-02
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 7.62E-01 -2.26E-02 -9.39E-02
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 3.99E-07 6.84E-02 4.10E-01
Myelofibrosis 2A20.2 Whole blood 9.40E-01 -4.28E-02 -2.79E-01
Myocardial infarction BA41-BA50 Peripheral blood 2.37E-03 2.25E-01 7.32E-01
Myopathy 8C70.6 Muscle tissue 1.51E-02 -7.89E-01 -1.41E+00
Neonatal sepsis KA60 Whole blood 7.02E-01 -1.59E-02 -7.28E-02
Neuroectodermal tumour 2A00.11 Brain stem tissue 3.12E-02 -2.98E-01 -1.13E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 5.24E-01 1.24E-01 1.95E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 7.13E-03 4.43E-01 1.98E+00
Olive pollen allergy CA08.00 Peripheral blood 3.98E-01 4.63E-02 1.14E+00
Oral cancer 2B6E Oral tissue 3.12E-04 -2.64E-01 -5.47E-01
Osteoarthritis FA00-FA0Z Synovial tissue 5.79E-01 7.84E-02 1.65E-01
Osteoporosis FB83.1 Bone marrow 6.42E-02 -2.11E-01 -3.48E+00
Ovarian cancer 2C73 Ovarian tissue 4.46E-02 8.66E-02 5.02E-01
Pancreatic cancer 2C10 Pancreas 1.68E-01 -5.42E-01 -1.09E+00
Parkinson's disease 8A00.0 Substantia nigra tissue 4.31E-01 2.50E-02 2.15E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 2.01E-01 7.29E-02 4.96E-01
Pituitary cancer 2D12 Pituitary tissue 3.31E-03 3.10E-01 1.14E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 3.28E-03 4.67E-01 2.17E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 1.25E-02 2.22E-01 1.22E+00
Polycythemia vera 2A20.4 Whole blood 1.60E-04 9.59E-02 7.04E-01
Pompe disease 5C51.3 Biceps muscle 8.77E-01 -3.40E-02 -1.09E-01
Preterm birth KA21.4Z Myometrium 6.70E-01 -1.71E-02 -1.88E-01
Prostate cancer 2C82 Prostate 4.73E-01 -7.21E-02 -1.40E-01
Psoriasis EA90 Skin 1.19E-02 5.35E-02 2.14E-01
Rectal cancer 2B92 Rectal colon tissue 7.07E-03 -4.28E-01 -1.89E+00
Renal cancer 2C90-2C91 Kidney 3.40E-02 -7.73E-01 -9.44E-01
Retinoblastoma 2D02.2 Uvea 2.49E-01 -2.88E-02 -2.11E-01
Rheumatoid arthritis FA20 Synovial tissue 2.60E-02 -6.19E-01 -1.39E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 5.42E-02 -1.64E-01 -4.69E-01
Schizophrenia 6A20 Prefrontal cortex 2.76E-01 1.12E-02 3.04E-02
Schizophrenia 6A20 Superior temporal cortex 1.19E-01 -8.92E-02 -8.35E-01
Scleroderma 4A42.Z Whole blood 1.26E-02 -1.33E-01 -1.09E+00
Seizure 8A60-8A6Z Whole blood 9.96E-01 -3.46E-02 -2.64E-01
Sensitive skin EK0Z Skin 5.68E-01 1.59E-02 1.31E-01
Sepsis with septic shock 1G41 Whole blood 2.66E-01 -4.93E-02 -2.39E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 3.25E-01 -2.54E-02 -2.49E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 3.41E-01 1.58E-02 7.72E-02
Simpson golabi behmel syndrome LD2C Adipose tissue 8.77E-01 1.31E-01 2.12E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 3.22E-01 -2.49E-01 -1.38E+00
Skin cancer 2C30-2C3Z Skin 8.31E-15 -2.47E-01 -7.47E-01
Thrombocythemia 3B63 Whole blood 1.75E-01 5.15E-02 3.51E-01
Thrombocytopenia 3B64 Whole blood 9.07E-02 2.11E-01 4.73E-01
Thyroid cancer 2D10 Thyroid 2.93E-11 3.99E-01 1.44E+00
Tibial muscular dystrophy 8C75 Muscle tissue 1.40E-03 -7.01E-01 -1.07E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 1.24E-01 2.49E-01 1.41E+00
Type 2 diabetes 5A11 Liver tissue 1.50E-02 -6.74E-01 -2.34E+00
Ureter cancer 2C92 Urothelium 3.85E-01 3.05E-02 1.83E-01
Uterine cancer 2C78 Endometrium tissue 6.67E-01 8.96E-03 4.07E-02
Vitiligo ED63.0 Skin 7.22E-03 -2.30E-01 -1.95E+00
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⏷ Show the Full List of Expression Under 107 Diseases

References

1 The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 3.A.1.208.10)
2 Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res. 2002 Nov 1;62(21):6172-7.