Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT8ACN1)

DTP Name Sodium/myo-inositol cotransporter (SLC5A3)
Gene Name SLC5A3
UniProt ID
P53794 (SC5A3_HUMAN)
VARIDT ID
DTD0423
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms BCW2; Na(+)/myo-inositol cotransporter; SLC5A3; SMIT; SMIT1; Sodium/myo-inositol transporter 1; Solute carrier family 5 member 3
DTP Family Solute:Sodium Symporter (SSS) Family ;
Sequence
MRAVLDTADIAIVALYFILVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVAIGASLFVSNI
GSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGH
RIQVYFAALSLILYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVA
VIYTDTLQALLMIIGALTLMIISIMEIGGFEEVKRRYMLASPDVTSILLTYNLSNTNSCN
VSPKKEALKMLRNPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTL
MAGFLKLLPMFIIVVPGMISRILFTDDIACINPEHCMLVCGSRAGCSNIAYPRLVMKLVP
VGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLIRKSASSRELMIVGRIFVAFMVV
ISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVL
GAVRLILAFAYRAPECDQPDNRPGFIKDIHYMYVATGLFWVTGLITVIVSLLTPPPTKEQ
IRTTTFWSKKNLVVKENCSPKEEPYQMQEKSILRCSENNETINHIIPNGKSEDSIKGLQP
EDVNLLVTCREEGNPVASLGHSEAETPVDAYSNGQAALMGEKERKKETDDGGRYWKFIDW
FCGFKSKSLSKRSLRDLMEEEAVCLQMLEETRQVKVILNIGLFAVCSLGIFMFVYFSL
Function This transporter prevents intracellular accumulation of high concentrations of myo-inositol that result in impairment of cellular function.
Endogenous Substrate(s) Na+
TCDB ID
2.A.21.3.14
Gene ID
6526
Reactome Pathway
Inositol transporters (R-HSA-429593 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Myo-inositol DMQKSGI Alzheimer disease 8A20 Phase 2 [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 4.58E-01 -2.78E-01 -2.92E-01
Adrenocortical carcinoma 2D11.Z Kidney 2.74E-01 1.25E-01 2.04E-01
Alopecia ED70 Skin from scalp 3.55E-01 -3.48E-02 -1.27E-01
Alzheimer's disease 8A20 Entorhinal cortex 6.58E-06 4.68E-01 9.02E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 9.64E-02 -6.13E-01 -9.04E-01
Aortic stenosis BB70 Calcified aortic valve 4.70E-01 -4.45E-01 -3.77E-01
Apnea 7A40 Hyperplastic tonsil 7.79E-02 9.47E-01 1.48E+00
Arthropathy FA00-FA5Z Peripheral blood 2.36E-01 -4.04E-02 -1.16E-01
Asthma CA23 Nasal and bronchial airway 1.57E-04 2.01E-01 2.63E-01
Atopic dermatitis EA80 Skin 4.68E-01 1.63E-01 3.26E-01
Autism 6A02 Whole blood 6.23E-02 1.71E-01 3.85E-01
Autoimmune uveitis 9A96 Peripheral monocyte 1.30E-02 2.09E+00 1.01E+01
Autosomal dominant monocytopenia 4B04 Whole blood 6.91E-01 3.43E-02 5.97E-02
Bacterial infection of gingival 1C1H Gingival tissue 1.86E-01 4.45E-02 1.03E-01
Batten disease 5C56.1 Whole blood 5.37E-01 3.75E-02 1.68E-01
Behcet's disease 4A62 Peripheral blood 8.37E-01 -8.70E-02 -2.01E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 1.05E-01 4.32E-02 2.29E-01
Bladder cancer 2C94 Bladder tissue 2.47E-02 1.44E-01 8.00E-01
Breast cancer 2C60-2C6Z Breast tissue 5.82E-01 -2.05E-03 -2.90E-03
Cardioembolic stroke 8B11.20 Whole blood 2.63E-04 -3.17E-01 -1.20E+00
Cervical cancer 2C77 Cervical tissue 4.41E-03 4.84E-01 8.33E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 5.23E-01 -1.91E-01 -2.20E-01
Chronic hepatitis C 1E51.1 Whole blood 8.36E-01 6.07E-02 1.93E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 4.98E-01 1.27E-01 2.86E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 5.82E-01 -4.32E-02 -1.09E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 1.52E-01 6.73E-01 1.30E+00
Colon cancer 2B90 Colon tissue 4.31E-10 -2.76E-01 -6.06E-01
Coronary artery disease BA80-BA8Z Peripheral blood 3.15E-01 1.02E+00 6.29E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 6.07E-01 1.05E-01 1.19E-01
Endometriosis GA10 Endometrium tissue 9.16E-02 -7.70E-01 -5.49E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 9.94E-01 3.17E-02 8.30E-02
Familial hypercholesterolemia 5C80.00 Whole blood 1.61E-04 7.07E-01 1.35E+00
Gastric cancer 2B72 Gastric tissue 1.00E+00 1.37E-01 1.07E-01
Glioblastopma 2A00.00 Nervous tissue 5.57E-17 3.29E-01 4.49E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.75E-01 1.98E-01 2.28E-01
Head and neck cancer 2D42 Head and neck tissue 1.13E-50 9.90E-01 2.87E+00
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 9.60E-01 2.66E-01 2.40E-01
Huntington's disease 8A01.10 Whole blood 5.67E-01 -1.64E-01 -4.98E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 3.16E-01 8.08E-02 1.82E-01
Immunodeficiency 4A00-4A20 Peripheral blood 2.37E-01 -1.90E-01 -4.93E-01
Influenza 1.00E+30 Whole blood 9.59E-03 -1.77E+00 -3.11E+00
Interstitial cystitis GC00.3 Bladder tissue 9.94E-01 -5.22E-02 -2.36E-01
Intracranial aneurysm 8B01.0 Intracranial artery 2.11E-02 -1.13E+00 -1.45E+00
Irritable bowel syndrome DD91.0 Rectal colon tissue 1.87E-01 6.05E-02 2.32E-01
Ischemic stroke 8B11 Peripheral blood 5.17E-01 -1.53E-01 -2.97E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 1.77E-02 3.36E-02 5.28E-02
Lateral sclerosis 8B60.4 Cervical spinal cord 1.63E-01 -2.63E-01 -3.45E-01
Lateral sclerosis 8B60.4 Skin 7.09E-01 -2.42E-01 -7.05E-01
Liver cancer 2C12.0 Liver tissue 4.73E-03 -3.18E-01 -5.20E-01
Liver failure DB99.7-DB99.8 Liver tissue 4.92E-01 -6.87E-03 -1.29E-02
Lung cancer 2C25 Lung tissue 7.00E-71 9.32E-01 2.11E+00
Lupus erythematosus 4A40 Whole blood 9.63E-10 -3.51E-01 -6.40E-01
Major depressive disorder 6A70-6A7Z Whole blood 9.25E-02 -2.37E-01 -5.88E-01
Major depressive disorder 6A70-6A7Z Hippocampus 8.66E-01 -2.33E-02 -1.19E-01
Melanoma 2C30 Skin 1.36E-01 1.58E-01 1.83E-01
Multiple myeloma 2A83.1 Bone marrow 6.16E-01 8.84E-02 2.09E-01
Multiple myeloma 2A83.1 Peripheral blood 4.16E-01 -1.93E-02 -5.88E-02
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 5.23E-01 3.78E-02 1.04E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 2.55E-03 3.17E-01 5.56E-01
Myelofibrosis 2A20.2 Whole blood 5.58E-01 -2.97E-01 -4.72E-01
Myocardial infarction BA41-BA50 Peripheral blood 2.08E-02 -1.06E-01 -1.63E-01
Myopathy 8C70.6 Muscle tissue 3.41E-02 7.66E-01 1.14E+00
Neonatal sepsis KA60 Whole blood 1.20E-16 -9.95E-01 -1.31E+00
Neuroectodermal tumour 2A00.11 Brain stem tissue 4.46E-07 2.25E+00 3.63E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 4.07E-02 -5.34E-01 -1.28E+00
Obesity related type 2 diabetes 5A11 Omental adipose tissue 1.40E-01 1.35E-01 4.29E-01
Olive pollen allergy CA08.00 Peripheral blood 2.00E-02 -9.25E-01 -1.83E+00
Oral cancer 2B6E Oral tissue 2.55E-07 9.70E-01 1.11E+00
Osteoarthritis FA00-FA0Z Synovial tissue 5.29E-01 -5.22E-01 -5.63E-01
Osteoporosis FB83.1 Bone marrow 2.69E-02 -1.15E+00 -1.44E+00
Ovarian cancer 2C73 Ovarian tissue 2.03E-03 9.95E-01 1.50E+00
Pancreatic cancer 2C10 Pancreas 1.63E-03 7.84E-01 9.46E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 1.06E-03 6.89E-01 1.46E+00
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 1.73E-02 -3.25E-01 -7.30E-01
Pituitary cancer 2D12 Pituitary tissue 9.74E-01 -1.74E-02 -3.20E-02
Pituitary gonadotrope tumour 2D12 Pituitary tissue 1.81E-01 2.74E-01 4.41E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 5.39E-01 1.06E-01 2.44E-01
Polycythemia vera 2A20.4 Whole blood 3.55E-01 -3.05E-01 -4.92E-01
Pompe disease 5C51.3 Biceps muscle 9.80E-06 9.02E-01 2.40E+00
Preterm birth KA21.4Z Myometrium 1.47E-01 -9.19E-01 -9.32E-01
Prostate cancer 2C82 Prostate 2.03E-02 -8.23E-02 -1.18E-01
Psoriasis EA90 Skin 2.37E-04 -2.24E-01 -3.76E-01
Rectal cancer 2B92 Rectal colon tissue 4.10E-01 7.90E-02 2.15E-01
Renal cancer 2C90-2C91 Kidney 7.39E-04 -1.74E+00 -1.66E+00
Retinoblastoma 2D02.2 Uvea 6.84E-04 4.39E-01 9.34E-01
Rheumatoid arthritis FA20 Synovial tissue 6.87E-01 2.10E-01 3.23E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 4.31E-01 9.39E-02 2.85E-01
Schizophrenia 6A20 Prefrontal cortex 7.48E-01 -9.61E-02 -2.55E-01
Schizophrenia 6A20 Superior temporal cortex 1.69E-02 4.36E-01 1.07E+00
Scleroderma 4A42.Z Whole blood 7.56E-03 -2.93E-01 -1.25E+00
Seizure 8A60-8A6Z Whole blood 2.04E-01 3.71E-01 5.50E-01
Sensitive skin EK0Z Skin 4.02E-01 8.73E-02 3.36E-01
Sepsis with septic shock 1G41 Whole blood 1.32E-34 -1.01E+00 -1.60E+00
Shwachman-Diamond syndrome 3A70.0 Bone marrow 8.01E-01 -8.76E-01 -7.98E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 6.00E-03 -1.56E+00 -1.23E+00
Simpson golabi behmel syndrome LD2C Adipose tissue 9.80E-01 -1.44E-01 -1.31E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 7.68E-01 2.26E-01 3.36E-01
Skin cancer 2C30-2C3Z Skin 1.75E-23 6.75E-01 9.73E-01
Thrombocythemia 3B63 Whole blood 2.49E-01 -2.74E-01 -4.38E-01
Thrombocytopenia 3B64 Whole blood 3.68E-01 -3.07E-01 -3.43E-01
Thyroid cancer 2D10 Thyroid 4.59E-17 -5.03E-01 -9.22E-01
Tibial muscular dystrophy 8C75 Muscle tissue 8.55E-01 -1.37E-01 -1.25E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 8.25E-01 -1.69E-01 -7.71E-01
Type 2 diabetes 5A11 Liver tissue 2.03E-01 1.94E-01 8.28E-01
Ureter cancer 2C92 Urothelium 1.09E-01 2.51E-01 9.88E-01
Uterine cancer 2C78 Endometrium tissue 5.84E-01 -1.42E-01 -1.23E-01
Vitiligo ED63.0 Skin 2.93E-02 6.44E-01 1.62E+00
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⏷ Show the Full List of Expression Under 107 Diseases

References

1 Identification of a novel Na+/myo-inositol cotransporter. J Biol Chem. 2002 Sep 20;277(38):35219-24.