Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DT9KFDT)

• DTP Name: Small conductance calcium-activated potassium channel protein 1 (KCNN1)
• Gene Name: KCNN1
• UniProt ID: Q92952 (KCNN1_HUMAN)
• VARIDT ID: DTD0543
• Synonyms: SK1; SKCa 1; SKCa1; KCa2.1; KCNN1; SK
• DTP Family: Voltage-gated Ion Channel (VIC) Superfamily
• Sequence:
  MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPR
  GQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVV
  MVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIA
  MTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYL
  LGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWT
  VRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTAL
  VVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARV
  RKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEA
  RLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPS
  DCG
• Function: This transporter is a voltage-independent potassium channel activated by intracellular calcium.
• TCDB ID: 1.A.1.16.6
• Gene ID: 3780
• KEGG Pathway:
  Insulin secretion (hsa04911)
  GnRH secretion (hsa04929)
• Reactome Pathway: Ca2+ activated K+ channels (R-HSA-1296052)

The Drug Therapeutic Target (DTT) Role of This DTP

• DTP DTT Name: Calcium-activated potassium channel KCa2.1 (KCNN1) DTT Info
• DTP DTT Type: Clinical trial

1 Clinical Trial Drug(s) Targeting This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
dequalinium	DMXM19W	Myelopathy	8B42	Clinical trial	[1]

5 Investigative Drug(s) Targeting This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
apamin	DMYNBK5	Discovery agent	N.A.	Investigative	[1]
EBIO	DMPKI0N	Discovery agent	N.A.	Investigative	[2]
UCL1684	DMZNJFU	Discovery agent	N.A.	Investigative	[2]
UCL1848	DM2CN0A	Discovery agent	N.A.	Investigative	[3]
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[2]

References

• [1] Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol. 2000 Mar;129(5):991-9.
• [2] Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55.
• [3] The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. Br J Pharmacol. 2000 Feb;129(4):627-30.