Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTC54PX)

DTP Name Alanine/serine/cysteine/threonine transporter 1 (SLC1A4)
Gene Name SLC1A4
UniProt ID
P43007 (SATT_HUMAN)
VARIDT ID
DTD0132
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms ASCT-1; ASCT1; Neutral amino acid transporter A; SATT; SLC1A4; SPATCCM; Solute carrier family 1 member 4
DTP Family Dicarboxylate/Amino Acid:Cation (Na(+) Or H(+)) Symporter (DAACS) Family ;
Tissue Specificity Expressed mostly in brain, muscle, andpancreas but detected in all tissues examined.
Sequence
MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGA
ALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAY
FGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFP
SNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKL
GSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFA
SILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENN
GVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGA
AGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQK
ATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL
Function This tranporter exhibits sodium dependence and mediates the transport of alanine, serine, cysteine, and threonine.
Endogenous Substrate(s) Cysteine; Na+; Serine
TCDB ID
2.A.23.3.1
Gene ID
6509
Reactome Pathway
Amino acid transport across the plasma membrane (R-HSA-352230 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
2 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-alanine DMZDN4W Dietary shortage 5B5K Approved [1]
D-Serine DM3YH4I N. A. N. A. Phase 4 [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 5.94E-02 -1.66E-01 -3.80E-01
Adrenocortical carcinoma 2D11.Z Kidney 1.24E-05 -5.30E-01 -1.27E+00
Alopecia ED70 Skin from scalp 2.11E-02 -1.72E-01 -6.35E-01
Alzheimer's disease 8A20 Entorhinal cortex 2.73E-01 -1.32E-01 -3.19E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 4.76E-02 2.38E-01 7.80E-01
Aortic stenosis BB70 Calcified aortic valve 9.96E-01 -7.80E-02 -8.52E-02
Apnea 7A40 Hyperplastic tonsil 1.31E-01 -4.40E-01 -6.81E-01
Arthropathy FA00-FA5Z Peripheral blood 4.45E-01 3.20E-02 2.07E-01
Asthma CA23 Nasal and bronchial airway 6.04E-01 5.51E-02 1.15E-01
Atopic dermatitis EA80 Skin 3.48E-03 2.13E-01 1.32E+00
Autism 6A02 Whole blood 6.05E-01 3.93E-02 9.04E-02
Autoimmune uveitis 9A96 Peripheral monocyte 3.44E-01 -2.34E-01 -5.51E-01
Autosomal dominant monocytopenia 4B04 Whole blood 7.72E-01 1.85E-01 3.25E-01
Bacterial infection of gingival 1C1H Gingival tissue 3.28E-11 4.20E-01 1.15E+00
Batten disease 5C56.1 Whole blood 5.69E-01 -1.78E-01 -5.35E-01
Behcet's disease 4A62 Peripheral blood 8.14E-01 1.24E-02 3.15E-02
Bipolar disorder 6A60-6A6Z Prefrontal cortex 8.79E-02 6.38E-02 2.19E-01
Bladder cancer 2C94 Bladder tissue 2.76E-02 3.74E-01 1.09E+00
Breast cancer 2C60-2C6Z Breast tissue 6.61E-34 6.79E-01 9.19E-01
Cardioembolic stroke 8B11.20 Whole blood 8.58E-01 1.91E-02 5.70E-02
Cervical cancer 2C77 Cervical tissue 2.14E-02 -6.27E-01 -8.92E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 3.37E-01 -8.80E-03 -2.72E-02
Chronic hepatitis C 1E51.1 Whole blood 9.37E-01 -2.73E-02 -5.03E-02
Chronic obstructive pulmonary disease CA22 Lung tissue 2.68E-01 -6.19E-02 -1.36E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 5.58E-02 1.05E-01 2.93E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 1.77E-03 -5.85E-01 -1.60E+00
Colon cancer 2B90 Colon tissue 3.49E-42 5.81E-01 1.47E+00
Coronary artery disease BA80-BA8Z Peripheral blood 1.85E-02 5.59E-01 4.53E+00
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 7.27E-01 -1.27E-01 -2.14E-01
Endometriosis GA10 Endometrium tissue 2.23E-01 -6.20E-01 -7.47E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 8.27E-01 -9.08E-02 -5.47E-01
Familial hypercholesterolemia 5C80.00 Whole blood 3.41E-04 6.85E-01 2.14E+00
Gastric cancer 2B72 Gastric tissue 8.31E-01 -2.31E-01 -3.83E-01
Glioblastopma 2A00.00 Nervous tissue 5.13E-07 -2.76E-01 -4.85E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 6.61E-01 -1.27E-02 -3.00E-02
Head and neck cancer 2D42 Head and neck tissue 2.03E-06 2.95E-01 7.39E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 1.20E-01 1.51E-01 3.40E-01
Huntington's disease 8A01.10 Whole blood 1.82E-01 -1.21E-01 -5.28E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 1.24E-01 3.04E-01 7.96E-01
Immunodeficiency 4A00-4A20 Peripheral blood 6.16E-03 5.41E-01 1.73E+00
Influenza 1.00E+30 Whole blood 2.53E-01 -9.22E-02 -8.14E-01
Interstitial cystitis GC00.3 Bladder tissue 6.31E-05 1.50E+00 4.45E+00
Intracranial aneurysm 8B01.0 Intracranial artery 8.45E-01 -1.40E-01 -2.73E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 3.06E-01 -8.24E-02 -2.44E-01
Ischemic stroke 8B11 Peripheral blood 5.59E-01 -6.30E-02 -2.65E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 6.61E-01 -3.63E-02 -7.46E-02
Lateral sclerosis 8B60.4 Cervical spinal cord 5.40E-01 8.03E-02 1.26E-01
Lateral sclerosis 8B60.4 Skin 6.77E-01 -2.34E-01 -2.79E-01
Liver cancer 2C12.0 Liver tissue 7.32E-04 1.11E+00 1.04E+00
Liver failure DB99.7-DB99.8 Liver tissue 6.24E-01 6.68E-02 8.74E-02
Lung cancer 2C25 Lung tissue 9.32E-77 1.11E+00 2.30E+00
Lupus erythematosus 4A40 Whole blood 1.02E-01 7.61E-02 1.36E-01
Major depressive disorder 6A70-6A7Z Whole blood 7.69E-01 4.16E-02 1.34E-01
Major depressive disorder 6A70-6A7Z Hippocampus 5.47E-02 -9.78E-02 -3.58E-01
Melanoma 2C30 Skin 6.37E-01 2.27E-02 2.72E-02
Multiple myeloma 2A83.1 Bone marrow 1.05E-05 1.20E+00 3.79E+00
Multiple myeloma 2A83.1 Peripheral blood 5.47E-01 -2.21E-01 -1.66E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 3.44E-01 1.94E-01 3.02E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 6.22E-08 -3.66E-01 -1.23E+00
Myelofibrosis 2A20.2 Whole blood 1.75E-05 4.59E-01 2.10E+00
Myocardial infarction BA41-BA50 Peripheral blood 9.40E-01 -9.54E-02 -1.07E-01
Myopathy 8C70.6 Muscle tissue 4.66E-02 -5.77E-01 -1.31E+00
Neonatal sepsis KA60 Whole blood 4.99E-01 9.61E-03 2.78E-02
Neuroectodermal tumour 2A00.11 Brain stem tissue 4.52E-02 2.99E-01 6.94E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 4.64E-01 -1.18E-01 -4.06E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 5.32E-01 4.63E-02 3.18E-01
Olive pollen allergy CA08.00 Peripheral blood 7.11E-01 -3.64E-01 -4.04E-01
Oral cancer 2B6E Oral tissue 2.39E-02 4.28E-01 4.42E-01
Osteoarthritis FA00-FA0Z Synovial tissue 8.09E-01 1.20E-01 2.55E-01
Osteoporosis FB83.1 Bone marrow 1.19E-01 4.94E-01 1.44E+00
Ovarian cancer 2C73 Ovarian tissue 1.38E-01 -4.99E-01 -1.03E+00
Pancreatic cancer 2C10 Pancreas 2.87E-03 -6.70E-01 -1.01E+00
Parkinson's disease 8A00.0 Substantia nigra tissue 5.71E-01 -2.07E-01 -4.63E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 3.78E-02 9.48E-02 3.66E-01
Pituitary cancer 2D12 Pituitary tissue 8.67E-02 2.61E-01 6.86E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 7.66E-01 -4.72E-04 -1.07E-03
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 2.56E-01 1.08E-01 3.04E-01
Polycythemia vera 2A20.4 Whole blood 7.29E-02 6.18E-02 3.81E-01
Pompe disease 5C51.3 Biceps muscle 6.19E-01 7.90E-04 8.23E-04
Preterm birth KA21.4Z Myometrium 5.74E-01 3.48E-02 9.00E-02
Prostate cancer 2C82 Prostate 2.58E-06 1.08E+00 1.47E+00
Psoriasis EA90 Skin 7.35E-19 4.03E-01 1.06E+00
Rectal cancer 2B92 Rectal colon tissue 7.02E-02 1.89E-01 5.96E-01
Renal cancer 2C90-2C91 Kidney 1.05E-06 1.10E+00 3.35E+00
Retinoblastoma 2D02.2 Uvea 4.23E-01 2.19E-01 6.51E-01
Rheumatoid arthritis FA20 Synovial tissue 2.93E-02 -7.62E-01 -1.84E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 9.27E-01 -7.52E-02 -2.40E-01
Schizophrenia 6A20 Prefrontal cortex 3.33E-01 -1.01E-01 -1.26E-01
Schizophrenia 6A20 Superior temporal cortex 1.93E-01 1.65E-01 5.95E-01
Scleroderma 4A42.Z Whole blood 2.66E-05 3.12E-01 1.78E+00
Seizure 8A60-8A6Z Whole blood 7.20E-01 4.87E-02 8.62E-02
Sensitive skin EK0Z Skin 7.65E-01 -1.54E-01 -5.89E-01
Sepsis with septic shock 1G41 Whole blood 3.24E-02 6.64E-02 1.91E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 2.46E-01 -1.90E-01 -1.22E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 2.43E-02 -1.24E-01 -7.36E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 4.28E-01 1.02E+00 1.09E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 1.38E-01 4.43E-01 1.63E+00
Skin cancer 2C30-2C3Z Skin 2.46E-14 6.40E-01 1.09E+00
Thrombocythemia 3B63 Whole blood 1.27E-04 2.19E-01 1.25E+00
Thrombocytopenia 3B64 Whole blood 8.07E-01 -1.65E-01 -2.15E-01
Thyroid cancer 2D10 Thyroid 4.28E-07 6.26E-01 8.71E-01
Tibial muscular dystrophy 8C75 Muscle tissue 7.29E-04 -6.81E-01 -9.92E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 6.92E-01 -3.13E-01 -8.10E-01
Type 2 diabetes 5A11 Liver tissue 1.35E-01 1.81E-01 1.02E+00
Ureter cancer 2C92 Urothelium 2.20E-01 1.38E-01 5.68E-01
Uterine cancer 2C78 Endometrium tissue 4.19E-09 -5.93E-01 -7.86E-01
Vitiligo ED63.0 Skin 2.26E-03 -2.92E-01 -1.35E+00
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⏷ Show the Full List of Expression Under 107 Diseases

Drug Affinity of This DTP Assessed by Cell Line

Approved Drug(s)
Drug Name Highest Status Cell Line Affinity REF
L-alanine Approved Rat hippocampal astrocyte-ASCT1 Km = 194 microM [1]
D-Serine Phase 4 Oocytes-ASCT1 Km = 206 microM [1]
D-Serine Phase 4 Rat hippocampal astrocyte-ASCT1 Km = 2200 microM [1]

References

1 D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551.