Details of the Drug

General Information of Drug (ID: DM3YH4I)

Drug Name
D-Serine
Synonyms
D-serine; 312-84-5; (R)-2-amino-3-hydroxypropanoic acid; (2R)-2-amino-3-hydroxypropanoic acid; Serine D-form; (R)-Serine; Serine, D-; d-(+)-serine; D-2-Amino-3-hydroxypropionic Acid; D-Serin; D-Ser; UNII-1K77H2Z9B1; EINECS 206-229-4; MFCD00004269; NSC 77689; (2R)-2-amino-3-hydroxy-propanoic acid; AI3-18476; CHEMBL285123; CHEBI:16523; MTCFGRXMJLQNBG-UWTATZPHSA-N; 1K77H2Z9B1; (R)-2-Amino-3-hydroxypropionic acid; DSN; NCGC00094363-03; D-Serine, 98%; D-2-Amino-3-hydroxypropanoic acid; NSC77689; serine d-; [3h]-d-serine; (2R)-serine
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 105.09
Logarithm of the Partition Coefficient (xlogp) -3.1
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C3H7NO3
IUPAC Name
(2R)-2-amino-3-hydroxypropanoic acid
Canonical SMILES
C([C@H](C(=O)O)N)O
InChI
InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
InChIKey
MTCFGRXMJLQNBG-UWTATZPHSA-N
Cross-matching ID
PubChem CID
71077
ChEBI ID
CHEBI:16523
CAS Number
312-84-5
DrugBank ID
DB03929
TTD ID
D02UDJ
VARIDT ID
DR00047
INTEDE ID
DR1922

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate receptor ionotropic NMDA 1 (NMDAR1) TTLD29N NMDZ1_HUMAN Inhibitor [1]
Strychnine-binding glycine receptor (GLRA1) TTF45NW GLRA1_HUMAN Inhibitor [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Alanine/serine/cysteine/threonine transporter 1 (SLC1A4) DTC54PX SATT_HUMAN Substrate [2]
Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DTW7AE3 AAAT_HUMAN Substrate [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
D-amino-acid oxidase (DAO) DERZQ2Y OXDA_HUMAN Substrate [3]
Serine racemase (SRR) DEKOQX7 SRR_HUMAN Substrate [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DTP ASCT2 9.03E-01 2.99E-01 6.85E-01
Alanine/serine/cysteine/threonine transporter 1 (SLC1A4) DTP ASCT1 3.44E-01 1.94E-01 3.02E-01
D-amino-acid oxidase (DAO) DME DAO 1.85E-01 2.08E-01 1.02E+00
Serine racemase (SRR) DME SRR 6.64E-01 9.51E-03 4.57E-02
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
2 D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551.
3 Focus on the role of D-serine and D-amino acid oxidase in amyotrophic lateral sclerosis/motor neuron disease (ALS). Front Mol Biosci. 2018 Feb 13;5:8.
4 D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986.