Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTEZCUM)

DTP Name Zinc transporter ZIP4 (SLC39A4)
Gene Name SLC39A4
UniProt ID
Q6P5W5 (S39A4_HUMAN)
VARIDT ID
DTD0345
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms AEZ; AWMS2; SLC39A4; Solute carrier family 39 member 4; ZIP-4; ZIP4; Zinc transporter ZIP4
DTP Family Zinc (Zn(2+))-Iron (Fe(2+)) Permease (ZIP) Family ;
Tissue Specificity Highly expressed in kidney, small intestine,stomach, colon, jejunum and duodenum.
Sequence
MASLVSLELGLLLAVLVVTATASPPAGLLSLLTSGQGALDQEALGGLLNTLADRVHCANG
PCGKCLSVEDALGLGEPEGSGLPPGPVLEARYVARLSAAAVLYLSNPEGTCEDARAGLWA
SHADHLLALLESPKALTPGLSWLLQRMQARAAGQTPKMACVDIPQLLEEAVGAGAPGSAG
GVLAALLDHVRSGSCFHALPSPQYFVDFVFQQHSSEVPMTLAELSALMQRLGVGREAHSD
HSHRHRGASSRDPVPLISSSNSSSVWDTVCLSARDVMAAYGLSEQAGVTPEAWAQLSPAL
LQQQLSGACTSQSRPPVQDQLSQSERYLYGSLATLLICLCAVFGLLLLTCTGCRGVTHYI
LQTFLSLAVGAVTGDAVLHLTPKVLGLHTHSEEGLSPQPTWRLLAMLAGLYAFFLFENLF
NLLLPRDPEDLEDGPCGHSSHSHGGHSHGVSLQLAPSELRQPKPPHEGSRADLVAEESPE
LLNPEPRRLSPELRLLPYMITLGDAVHNFADGLAVGAAFASSWKTGLATSLAVFCHELPH
ELGDFAALLHAGLSVRQALLLNLASALTAFAGLYVALAVGVSEESEAWILAVATGLFLYV
ALCDMLPAMLKVRDPRPWLLFLLHNVGLLGGWTVLLLLSLYEDDITF
Function This transporter regulated in response to zinc availability and plays an important role in cellular zinc homeostasis as a zinc transporter.
Endogenous Substrate(s) Zn2+
TCDB ID
2.A.5.4.1
Gene ID
55630
KEGG Pathway
Mineral absorption (hsa04978 )
Alzheimer disease (hsa05010 )
Parkinson disease (hsa05012 )
Reactome Pathway
Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) (R-HSA-5619088 )
Zinc influx into cells by the SLC39 gene family (R-HSA-442380 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zinc salts DMZ4R3Q Arthritis FA20 Approved [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 7.45E-21 6.17E-01 1.19E+00
Adrenocortical carcinoma 2D11.Z Kidney 9.74E-01 -2.94E-02 -5.40E-02
Alopecia ED70 Skin from scalp 1.67E-03 3.87E-01 6.15E-01
Alzheimer's disease 8A20 Entorhinal cortex 2.61E-03 -1.22E-01 -3.14E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 7.90E-02 4.20E-01 2.26E+00
Aortic stenosis BB70 Calcified aortic valve 1.34E-01 3.83E-01 1.08E+00
Apnea 7A40 Hyperplastic tonsil 6.47E-04 -1.02E+00 -2.28E+00
Arthropathy FA00-FA5Z Peripheral blood 1.29E-01 -1.94E-01 -5.66E-01
Asthma CA23 Nasal and bronchial airway 9.42E-01 -9.73E-02 -1.33E-01
Atopic dermatitis EA80 Skin 1.67E-04 3.15E-01 1.42E+00
Autism 6A02 Whole blood 3.70E-01 -6.42E-02 -2.22E-01
Autoimmune uveitis 9A96 Peripheral monocyte 8.95E-01 -2.77E-01 -7.90E-01
Autosomal dominant monocytopenia 4B04 Whole blood 9.28E-01 8.30E-02 2.54E-01
Bacterial infection of gingival 1C1H Gingival tissue 3.36E-01 -2.01E-03 -5.04E-03
Batten disease 5C56.1 Whole blood 7.05E-01 -5.70E-03 -2.22E-02
Behcet's disease 4A62 Peripheral blood 3.93E-01 1.45E-01 6.54E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 7.03E-01 2.01E-02 4.54E-02
Bladder cancer 2C94 Bladder tissue 8.28E-04 1.03E+00 1.68E+00
Breast cancer 2C60-2C6Z Breast tissue 1.77E-169 1.32E+00 3.15E+00
Cardioembolic stroke 8B11.20 Whole blood 5.33E-06 5.67E-01 1.23E+00
Cervical cancer 2C77 Cervical tissue 1.72E-01 2.21E-01 5.98E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 1.00E-01 2.47E-01 6.60E-01
Chronic hepatitis C 1E51.1 Whole blood 6.86E-01 4.82E-03 2.00E-02
Chronic obstructive pulmonary disease CA22 Lung tissue 9.33E-02 -2.76E-01 -5.54E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 6.77E-01 -3.20E-02 -5.69E-02
Chronic rhinosinusitis CA0A Sinus mucosa tissue 2.26E-02 4.80E-01 2.11E+00
Colon cancer 2B90 Colon tissue 9.63E-17 3.85E-01 8.64E-01
Coronary artery disease BA80-BA8Z Peripheral blood 4.21E-01 7.28E-02 1.73E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 9.70E-01 -1.93E-01 -3.60E-01
Endometriosis GA10 Endometrium tissue 2.06E-02 -3.35E-01 -4.79E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 9.89E-02 3.77E-02 1.93E-01
Familial hypercholesterolemia 5C80.00 Whole blood 2.73E-05 7.78E-01 1.99E+00
Gastric cancer 2B72 Gastric tissue 1.66E-02 1.45E+00 4.52E+00
Glioblastopma 2A00.00 Nervous tissue 6.80E-01 -9.93E-02 -1.97E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 7.86E-02 4.95E-02 1.10E-01
Head and neck cancer 2D42 Head and neck tissue 9.45E-20 7.90E-01 1.32E+00
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 3.00E-01 -8.26E-02 -2.83E-01
Huntington's disease 8A01.10 Whole blood 5.86E-01 1.00E-01 2.03E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 9.26E-01 1.48E-01 3.74E-01
Immunodeficiency 4A00-4A20 Peripheral blood 9.82E-01 7.98E-02 2.60E-01
Influenza 1.00E+30 Whole blood 4.24E-02 -4.08E-01 -2.65E+00
Interstitial cystitis GC00.3 Bladder tissue 5.45E-02 -6.13E-01 -1.32E+00
Intracranial aneurysm 8B01.0 Intracranial artery 7.30E-03 4.94E-01 1.08E+00
Irritable bowel syndrome DD91.0 Rectal colon tissue 7.81E-01 -6.65E-03 -1.20E-02
Ischemic stroke 8B11 Peripheral blood 4.47E-01 1.16E-01 4.45E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 4.88E-01 5.27E-02 1.05E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 5.44E-01 -1.23E-01 -7.61E-01
Lateral sclerosis 8B60.4 Skin 5.99E-01 1.35E-01 2.86E-01
Liver cancer 2C12.0 Liver tissue 1.23E-09 3.48E-01 8.44E-01
Liver failure DB99.7-DB99.8 Liver tissue 5.87E-05 1.12E+00 2.50E+00
Lung cancer 2C25 Lung tissue 1.50E-77 9.46E-01 2.18E+00
Lupus erythematosus 4A40 Whole blood 3.78E-01 -1.06E-02 -2.37E-02
Major depressive disorder 6A70-6A7Z Whole blood 8.20E-01 -7.37E-02 -1.56E-01
Major depressive disorder 6A70-6A7Z Hippocampus 9.62E-01 -2.19E-02 -5.07E-02
Melanoma 2C30 Skin 5.54E-03 2.37E-01 3.59E-01
Multiple myeloma 2A83.1 Bone marrow 4.52E-04 7.79E-01 2.08E+00
Multiple myeloma 2A83.1 Peripheral blood 4.85E-02 -3.37E-01 -1.15E+00
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 4.21E-01 -2.79E-01 -4.69E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 9.18E-04 1.51E-01 3.01E-01
Myelofibrosis 2A20.2 Whole blood 3.76E-04 4.06E-01 1.84E+00
Myocardial infarction BA41-BA50 Peripheral blood 1.15E-01 -4.71E-02 -6.91E-02
Myopathy 8C70.6 Muscle tissue 4.29E-01 7.67E-02 3.15E-01
Neonatal sepsis KA60 Whole blood 4.16E-02 6.72E-02 1.49E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 1.47E-05 5.75E-01 1.64E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 4.55E-01 -1.38E-01 -6.66E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 6.28E-01 5.57E-02 1.28E-01
Olive pollen allergy CA08.00 Peripheral blood 9.31E-01 7.73E-02 2.77E-01
Oral cancer 2B6E Oral tissue 2.11E-06 9.54E-01 1.31E+00
Osteoarthritis FA00-FA0Z Synovial tissue 3.02E-01 6.19E-01 3.92E-01
Osteoporosis FB83.1 Bone marrow 5.46E-01 4.84E-01 1.24E+00
Ovarian cancer 2C73 Ovarian tissue 3.74E-07 2.35E+00 4.81E+00
Pancreatic cancer 2C10 Pancreas 5.95E-06 8.45E-01 1.36E+00
Parkinson's disease 8A00.0 Substantia nigra tissue 6.04E-01 5.02E-02 2.08E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 2.24E-01 1.21E-01 3.79E-01
Pituitary cancer 2D12 Pituitary tissue 1.65E-04 1.02E+00 3.99E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 4.56E-03 9.18E-01 3.38E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 3.06E-01 8.50E-03 3.39E-02
Polycythemia vera 2A20.4 Whole blood 2.49E-01 1.13E-01 4.53E-01
Pompe disease 5C51.3 Biceps muscle 7.32E-05 8.65E-01 3.02E+00
Preterm birth KA21.4Z Myometrium 6.89E-01 1.44E-02 3.56E-02
Prostate cancer 2C82 Prostate 7.85E-02 2.81E-01 3.58E-01
Psoriasis EA90 Skin 8.74E-06 3.14E-01 8.95E-01
Rectal cancer 2B92 Rectal colon tissue 6.31E-03 6.41E-01 1.74E+00
Renal cancer 2C90-2C91 Kidney 9.97E-06 -1.38E+00 -2.67E+00
Retinoblastoma 2D02.2 Uvea 2.76E-08 2.91E+00 1.09E+01
Rheumatoid arthritis FA20 Synovial tissue 6.97E-05 1.64E+00 3.46E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 8.04E-01 4.72E-02 2.44E-01
Schizophrenia 6A20 Prefrontal cortex 8.44E-01 1.66E-02 2.86E-02
Schizophrenia 6A20 Superior temporal cortex 3.97E-01 -8.66E-04 -3.62E-03
Scleroderma 4A42.Z Whole blood 7.84E-04 -1.56E-01 -1.54E+00
Seizure 8A60-8A6Z Whole blood 9.14E-01 1.67E-01 3.65E-01
Sensitive skin EK0Z Skin 3.39E-01 -1.38E-01 -5.69E-01
Sepsis with septic shock 1G41 Whole blood 1.34E-03 8.95E-02 2.20E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 3.33E-03 -4.23E-01 -2.05E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 3.67E-01 2.47E-01 3.12E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 9.02E-01 4.29E-02 6.89E-02
Sjogren's syndrome 4A43.2 Salivary gland tissue 3.54E-03 -8.39E-01 -4.83E+00
Skin cancer 2C30-2C3Z Skin 9.58E-08 3.65E-01 7.36E-01
Thrombocythemia 3B63 Whole blood 1.88E-02 1.85E-01 7.86E-01
Thrombocytopenia 3B64 Whole blood 7.33E-01 5.71E-01 6.90E-01
Thyroid cancer 2D10 Thyroid 1.47E-14 -5.58E-01 -1.15E+00
Tibial muscular dystrophy 8C75 Muscle tissue 8.08E-01 -6.08E-02 -2.03E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 5.98E-01 3.16E-03 8.43E-03
Type 2 diabetes 5A11 Liver tissue 8.17E-01 3.09E-01 7.64E-01
Ureter cancer 2C92 Urothelium 3.42E-01 1.41E-01 4.24E-01
Uterine cancer 2C78 Endometrium tissue 4.90E-01 1.44E-01 1.31E-01
Vitiligo ED63.0 Skin 7.31E-01 1.47E-01 2.34E-01
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⏷ Show the Full List of Expression Under 107 Diseases

References

1 Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa. PLoS Genet. 2014 Feb 20;10(2):e1004128.