Details of the Drug

General Information of Drug (ID: DMZ4R3Q)

Drug Name
Zinc salts
Indication
Disease Entry ICD 11 Status REF
Arthritis FA20 Approved [1]
Cross-matching ID
TTD ID
D0K8AA
VARIDT ID
DR00068

Molecular Interaction Atlas of This Drug


Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Iron-regulated transporter 1 (SLC40A1) DTD3FHQ S40A1_HUMAN Substrate [2]
Zinc transporter ZIP8 (SLC39A8) DTLPQGT S39A8_HUMAN Substrate [3]
Zinc transporter ZIP14 (SLC39A14) DTZ6IJW S39AE_HUMAN Substrate [4]
Zinc transporter ZIP9 (SLC39A9) DTJH79E S39A9_HUMAN Substrate [5]
Zinc transporter SLC39A7 (SLC39A7) DTDQSAM S39A7_HUMAN Substrate [5]
Zinc transporter ZIP6 (SLC39A6) DTT1S93 S39A6_HUMAN Substrate [5]
Zinc transporter ZIP4 (SLC39A4) DTEZCUM S39A4_HUMAN Substrate [6]
Zinc transporter ZIP3 (SLC39A3) DTH08M7 S39A3_HUMAN Substrate [7]
Zinc transporter ZIP13 (SLC39A13) DTOTKBS S39AD_HUMAN Substrate [8]
Zinc transporter ZIP12 (SLC39A12) DT1UIT5 S39AC_HUMAN Substrate [9]
Zinc transporter ZIP11 (SLC39A11) DTEOAND S39AB_HUMAN Substrate [10]
Zinc transporter ZIP10 (SLC39A10) DTK02RZ S39AA_HUMAN Substrate [11]
Zinc transporter ZIP1 (SLC39A1) DTLWPXS S39A1_HUMAN Substrate [12]
Zinc transporter 9 (SLC30A9) DT2I79L ZNT9_HUMAN Substrate [13]
Zinc transporter 8 (SLC30A8) DT7NVLY ZNT8_HUMAN Substrate [14]
Zinc transporter 7 (SLC30A7) DTQK38X ZNT7_HUMAN Substrate [15]
Zinc transporter 6 (SLC30A6) DTKPRIL ZNT6_HUMAN Substrate [16]
Zinc transporter 5 (SLC30A5) DTVHQT2 ZNT5_HUMAN Substrate [16]
Zinc transporter 4 (SLC30A4) DT280XI ZNT4_HUMAN Substrate [17]
Zinc transporter 3 (SLC30A3) DTKMECW ZNT3_HUMAN Substrate [18]
Zinc transporter 2 (SLC30A2) DTIAF6C ZNT2_HUMAN Substrate [19]
Zinc transporter 10 (SLC30A10) DTYBI73 ZNT10_HUMAN Substrate [20]
Zinc transporter 1 (SLC30A1) DT1BO38 ZNT1_HUMAN Substrate [3]
Zinc transporter ZIP5 (SLC39A5) DTN9ACR S39A5_HUMAN Substrate [21]
Zinc transporter ZIP2 (SLC39A2) DTL8VXO S39A2_HUMAN Substrate [22]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Ferroportin-mediated iron transport: expression and regulation. Biochim Biophys Acta. 2012 Sep;1823(9):1426-33.
3 Zinc transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in mouse red blood cells are differentially regulated during erythroid development and by dietary zinc deficiency. J Nutr. 2008 Nov;138(11):2076-83.
4 SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1769-E1778.
5 A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition. Sci Rep. 2017 Jan 18;7:40313.
6 Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa. PLoS Genet. 2014 Feb 20;10(2):e1004128.
7 The SLC39 family of zinc transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):612-9.
8 Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos syndrome. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):E3530-8.
9 The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia. Nature. 2015 Aug 20;524(7565):356-60.
10 Gastric and colonic zinc transporter ZIP11 (Slc39a11) in mice responds to dietary zinc and exhibits nuclear localization. J Nutr. 2013 Dec;143(12):1882-8.
11 Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11780-5.
12 SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms. Biochem J. 2016 May 1;473(9):1113-24.
13 SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome. Brain. 2017 Apr 1;140(4):928-939.
14 Zinc transporter 8 (ZnT8) and cell function. Trends Endocrinol Metab. 2014 Aug;25(8):415-24.
15 Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation. J Biol Chem. 2007 Dec 21;282(51):37053-63.
16 Altered expression of two zinc transporters, SLC30A5 and SLC30A6, underlies a mammary gland disorder of reduced zinc secretion into milk. Genes Nutr. 2015 Sep;10(5):487.
17 Mutation analysis of the zinc transporter gene SLC30A4 reveals no association with periodic catatonia on chromosome 15q15. J Neural Transm (Vienna). 2003 Nov;110(11):1329-32.
18 Loss of synaptic Zn2+ transporter function increases risk of febrile seizures. Sci Rep. 2015 Dec 9;5:17816.
19 Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: a novel mechanism for zinc deficiency in a breast-fed infant. PLoS One. 2013 May 31;8(5):e64045.
20 Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease. Am J Hum Genet. 2012 Mar 9;90(3):467-77.
21 The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. J Biol Chem. 2004 Dec 3;279(49):51433-41.
22 Reassessment of the Transport Mechanism of the Human Zinc Transporter SLC39A2. Biochemistry. 2018 Jul 3;57(26):3976-3986.