Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTJ4NEG)

DTP Name ATP-binding cassette sub-family A member 2 (ABCA2)
Gene Name ABCA2
UniProt ID
Q9BZC7 (ABCA2_HUMAN)
VARIDT ID
DTD0040
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms ABC2; ABCA2; ATP-binding cassette 2; ATP-binding cassette transporter 2; KIAA1062
DTP Family ATP-Binding Cassette (ABC) Superfamily
Cholesterol/Phospholipid/Retinal (CPR) Flippase Family (ABCA)
Tissue Specificity Highly expressed in the brain, whereas lowerlevels of expression is observed in kidney and liver.
Sequence
MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEAFYTAAP
LTSAGILPVMQSLCPDGQRDEFGFLQYANSTVTQLLERLDRVVEEGNLFDPARPSLGSEL
EALRQHLEALSAGPGTSGSHLDRSTVSSFSLDSVARNPQELWRFLTQNLSLPNSTAQALL
AARVDPPEVYHLLFGPSSALDSQSGLHKGQEPWSRLGGNPLFRMEELLLAPALLEQLTCT
PGSGELGRILTVPESQKGALQGYRDAVCSGQAAARARRFSGLSAELRNQLDVAKVSQQLG
LDAPNGSDSSPQAPPPRRLQALLGDLLDAQKVLQDVDVLSALALLLPQGACTGRTPGPPA
SGAGGAANGTGAGAVMGPNATAEEGAPSAAALATPDTLQGQCSAFVQLWAGLQPILCGNN
RTIEPEALRRGNMSSLGFTSKEQRNLGLLVHLMTSNPKILYAPAGSEVDRVILKANETFA
FVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLRWLQQYVAELRLHPEALNLSLDELPPAL
RQDNFSLPSGMALLQQLDTIDNAACGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDN
VTVFASVIFQTRKDGSLPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGFV
WIQDMMERAIIDTFVGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVA
MTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHS
HVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHD
KITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLM
VDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVM
EEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVV
SFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLT
VEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGG
SRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLK
CCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIRKH
VASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVFLK
VSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSVGS
ARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVRQFH
GLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQP
RGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSS
GESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAG
PEMWTSAPSLPRLVREPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSE
YLLFTSDRFRLHRYGAITFGNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMP
TYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGTDVVIAIFIIV
AMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFV
FDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATV
ATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMK
SPFEWDIVTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRV
LRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKML
TGDESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWK
DEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKA
RRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGY
MITVRTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGV
LGIEDYSVSQTTLDNVFVNFAKKQSDNLEQQETEPPSALQSPLGCLLSLLRPRSAPTELR
ALVADEPEDLDTEDEGLISFEEERAQLSFNTDTLC
Function This transporter may have a role in macrophage lipid metabolism and neural development.
Endogenous Substrate(s) Lipids
TCDB ID
3.A.1.211.3
Gene ID
20
KEGG Pathway
ABC transporters (hsa02010 )
Lysosome (hsa04142 )
Reactome Pathway
ABC transporters in lipid homeostasis (R-HSA-1369062 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cholesterol DMR3J6S Discovery agent N.A. Investigative [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 2.16E-26 2.70E-01 1.16E+00
Adrenocortical carcinoma 2D11.Z Kidney 4.47E-01 4.66E-02 1.23E-01
Alopecia ED70 Skin from scalp 1.55E-01 -6.53E-02 -2.17E-01
Alzheimer's disease 8A20 Entorhinal cortex 2.47E-01 8.02E-02 1.35E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 7.65E-01 -8.35E-03 -6.39E-02
Aortic stenosis BB70 Calcified aortic valve 9.64E-01 -3.62E-02 -5.81E-02
Apnea 7A40 Hyperplastic tonsil 3.07E-01 -6.41E-02 -3.22E-01
Arthropathy FA00-FA5Z Peripheral blood 3.10E-01 -6.08E-02 -2.57E-01
Asthma CA23 Nasal and bronchial airway 2.02E-01 -4.77E-02 -1.45E-01
Atopic dermatitis EA80 Skin 4.26E-01 -3.64E-02 -1.26E-01
Autism 6A02 Whole blood 2.97E-01 1.25E-01 3.86E-01
Autoimmune uveitis 9A96 Peripheral monocyte 8.59E-01 5.08E-02 6.62E-01
Autosomal dominant monocytopenia 4B04 Whole blood 7.66E-01 -2.66E-02 -1.92E-01
Bacterial infection of gingival 1C1H Gingival tissue 7.52E-03 1.72E-01 5.76E-01
Batten disease 5C56.1 Whole blood 9.38E-01 6.97E-03 3.67E-02
Behcet's disease 4A62 Peripheral blood 8.19E-01 -1.95E-01 -5.30E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 9.52E-01 -3.10E-02 -1.15E-01
Bladder cancer 2C94 Bladder tissue 1.40E-01 5.05E-01 1.19E+00
Breast cancer 2C60-2C6Z Breast tissue 1.79E-02 5.43E-02 1.17E-01
Cardioembolic stroke 8B11.20 Whole blood 3.91E-07 -4.00E-01 -1.98E+00
Cervical cancer 2C77 Cervical tissue 1.42E-01 -1.37E-02 -8.18E-02
Childhood onset rheumatic disease FA20.Z Peripheral blood 9.34E-01 1.19E-01 2.76E-01
Chronic hepatitis C 1E51.1 Whole blood 6.31E-01 3.15E-02 1.97E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 5.45E-01 2.74E-02 8.44E-02
Chronic obstructive pulmonary disease CA22 Small airway epithelium 8.88E-02 1.49E-01 3.06E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 4.79E-01 2.10E-02 9.61E-02
Colon cancer 2B90 Colon tissue 7.43E-06 -1.41E-01 -4.52E-01
Coronary artery disease BA80-BA8Z Peripheral blood 2.01E-01 -3.15E-02 -3.82E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 9.63E-01 -2.91E-02 -1.18E-01
Endometriosis GA10 Endometrium tissue 6.40E-02 -4.21E-02 -1.24E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 1.61E-01 -3.78E-02 -3.85E-01
Familial hypercholesterolemia 5C80.00 Whole blood 2.63E-02 -1.60E-01 -5.86E-01
Gastric cancer 2B72 Gastric tissue 6.05E-01 -5.72E-02 -8.69E-02
Glioblastopma 2A00.00 Nervous tissue 5.53E-106 -2.42E+00 -1.92E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 3.73E-06 -9.14E-01 -2.82E+00
Head and neck cancer 2D42 Head and neck tissue 7.10E-03 -2.94E-02 -8.32E-02
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 8.97E-02 2.21E-01 3.13E-01
Huntington's disease 8A01.10 Whole blood 3.91E-01 7.97E-02 5.06E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 4.60E-02 8.93E-02 7.40E-01
Immunodeficiency 4A00-4A20 Peripheral blood 3.12E-01 8.36E-03 8.15E-02
Influenza 1.00E+30 Whole blood 8.91E-02 3.12E-01 2.39E+00
Interstitial cystitis GC00.3 Bladder tissue 9.87E-01 1.76E-02 4.93E-02
Intracranial aneurysm 8B01.0 Intracranial artery 6.10E-01 -1.49E-01 -4.94E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 1.41E-01 -4.49E-02 -2.36E-01
Ischemic stroke 8B11 Peripheral blood 6.83E-01 1.04E-01 3.20E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 7.44E-02 -9.80E-02 -3.58E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 2.62E-01 -7.76E-03 -2.67E-02
Lateral sclerosis 8B60.4 Skin 6.69E-01 5.76E-02 1.21E-01
Liver cancer 2C12.0 Liver tissue 5.33E-01 -6.17E-02 -1.55E-01
Liver failure DB99.7-DB99.8 Liver tissue 2.81E-03 1.89E-01 1.15E+00
Lung cancer 2C25 Lung tissue 4.90E-09 -1.53E-01 -6.05E-01
Lupus erythematosus 4A40 Whole blood 5.33E-01 2.10E-02 5.09E-02
Major depressive disorder 6A70-6A7Z Whole blood 3.21E-01 -2.86E-02 -1.36E-01
Major depressive disorder 6A70-6A7Z Hippocampus 5.50E-01 8.74E-02 3.02E-01
Melanoma 2C30 Skin 1.86E-02 -4.44E-01 -8.73E-01
Multiple myeloma 2A83.1 Bone marrow 2.01E-01 9.88E-02 4.53E-01
Multiple myeloma 2A83.1 Peripheral blood 5.55E-01 6.96E-02 2.79E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 2.82E-01 -1.12E-01 -4.36E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 8.64E-01 -5.42E-02 -3.46E-01
Myelofibrosis 2A20.2 Whole blood 7.34E-01 -1.07E-02 -8.01E-02
Myocardial infarction BA41-BA50 Peripheral blood 3.80E-01 -1.70E-01 -3.40E-01
Myopathy 8C70.6 Muscle tissue 1.89E-01 -2.05E-01 -9.33E-01
Neonatal sepsis KA60 Whole blood 1.41E-01 4.65E-02 1.45E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 3.82E-08 -3.80E+00 -5.50E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 2.62E-01 1.05E-01 8.83E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 2.56E-01 8.72E-03 1.09E-01
Olive pollen allergy CA08.00 Peripheral blood 3.03E-02 3.20E-01 1.76E+00
Oral cancer 2B6E Oral tissue 5.17E-12 -4.14E-01 -2.15E+00
Osteoarthritis FA00-FA0Z Synovial tissue 4.99E-01 -3.57E-01 -8.42E-01
Osteoporosis FB83.1 Bone marrow 7.37E-04 1.25E+00 3.93E+00
Ovarian cancer 2C73 Ovarian tissue 4.26E-01 4.50E-02 1.23E-01
Pancreatic cancer 2C10 Pancreas 4.45E-01 -1.93E-02 -5.72E-02
Parkinson's disease 8A00.0 Substantia nigra tissue 7.92E-01 9.37E-02 1.99E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 5.43E-04 -2.58E-01 -1.03E+00
Pituitary cancer 2D12 Pituitary tissue 5.09E-04 7.04E-01 1.68E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 4.14E-04 8.12E-01 2.10E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 6.18E-01 1.60E-02 6.53E-02
Polycythemia vera 2A20.4 Whole blood 7.95E-01 -4.07E-02 -3.58E-01
Pompe disease 5C51.3 Biceps muscle 8.64E-01 2.60E-02 1.92E-01
Preterm birth KA21.4Z Myometrium 3.46E-01 9.47E-02 8.50E-01
Prostate cancer 2C82 Prostate 4.54E-02 2.19E-01 6.17E-01
Psoriasis EA90 Skin 8.83E-01 9.63E-02 2.39E-01
Rectal cancer 2B92 Rectal colon tissue 6.09E-01 1.29E-01 3.97E-01
Renal cancer 2C90-2C91 Kidney 3.38E-01 -3.43E-01 -6.60E-01
Retinoblastoma 2D02.2 Uvea 1.65E-09 -8.32E-01 -4.23E+00
Rheumatoid arthritis FA20 Synovial tissue 3.10E-01 -1.09E-01 -2.24E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 2.48E-01 -4.03E-02 -2.30E-01
Schizophrenia 6A20 Prefrontal cortex 6.65E-02 -1.23E-01 -1.91E-01
Schizophrenia 6A20 Superior temporal cortex 2.73E-01 -1.02E-01 -2.21E-01
Scleroderma 4A42.Z Whole blood 1.53E-01 -1.26E-01 -4.53E-01
Seizure 8A60-8A6Z Whole blood 5.00E-01 9.00E-02 3.87E-01
Sensitive skin EK0Z Skin 9.53E-01 -4.58E-02 -1.76E-01
Sepsis with septic shock 1G41 Whole blood 3.34E-05 1.46E-01 4.63E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 6.93E-01 8.68E-02 5.52E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 1.84E-01 6.63E-02 2.72E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 9.31E-01 -6.74E-02 -1.36E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 4.45E-02 -4.34E-01 -2.71E+00
Skin cancer 2C30-2C3Z Skin 8.40E-01 -1.61E-02 -4.71E-02
Thrombocythemia 3B63 Whole blood 4.43E-01 -4.35E-02 -3.28E-01
Thrombocytopenia 3B64 Whole blood 5.40E-01 4.61E-01 4.69E-01
Thyroid cancer 2D10 Thyroid 1.39E-06 -2.98E-01 -5.66E-01
Tibial muscular dystrophy 8C75 Muscle tissue 1.31E-03 -4.07E-01 -8.45E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 5.11E-01 -6.49E-01 -1.88E+00
Type 2 diabetes 5A11 Liver tissue 6.59E-01 -3.74E-02 -1.14E-01
Ureter cancer 2C92 Urothelium 9.68E-02 9.96E-02 3.89E-01
Uterine cancer 2C78 Endometrium tissue 1.04E-04 -2.23E-01 -5.65E-01
Vitiligo ED63.0 Skin 3.75E-01 -7.35E-02 -5.34E-01
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⏷ Show the Full List of Expression Under 107 Diseases

References

1 The ATP-binding cassette transporter-2 (ABCA2) regulates cholesterol homeostasis and low-density lipoprotein receptor metabolism in N2a neuroblastoma cells. Biochim Biophys Acta. 2011 Dec;1811(12):1152-64.