Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTJYKDQ)

DTP Name Mitochondrial dicarboxylate carrier (SLC25A10)
Gene Name SLC25A10
UniProt ID
Q9UBX3 (DIC_HUMAN)
VARIDT ID
DTD0168
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms DIC; SLC25A10; Solute carrier family 25 member 10
DTP Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Present in high amounts in liver and kidney,and at lower levels in all the other tissues analyzed.
Sequence
MAAEARVSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALRVVRTDGILAL
YSGLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPA
DLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLS
CYDQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHC
AVETAKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGIKVPS
Function This transporter involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.
Endogenous Substrate(s) Succinate; Thiosulfate; Malate
TCDB ID
2.A.29.2.7
Gene ID
1468
KEGG Pathway
Proximal tubule bicarbonate reclamation (hsa04964 )
Reactome Pathway
Organic anion transporters (R-HSA-428643 )
Gluconeogenesis (R-HSA-70263 )
Sulfide oxidation to sulfate (R-HSA-1614517 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phosphate DMUXQG7 Constipation DD91.1 Approved [1]
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1 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
SULFATE DMW0ZBF Discovery agent N.A. Investigative [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 2.25E-02 8.54E-02 2.69E-01
Adrenocortical carcinoma 2D11.Z Kidney 1.84E-02 2.20E-01 6.49E-01
Alopecia ED70 Skin from scalp 7.22E-01 -8.61E-03 -2.81E-02
Alzheimer's disease 8A20 Entorhinal cortex 5.59E-01 -2.32E-02 -1.21E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 1.43E-01 4.30E-02 2.83E-01
Aortic stenosis BB70 Calcified aortic valve 6.43E-01 9.95E-02 3.35E-01
Apnea 7A40 Hyperplastic tonsil 3.21E-01 -2.64E-01 -1.22E+00
Arthropathy FA00-FA5Z Peripheral blood 8.65E-01 1.05E-02 7.96E-02
Asthma CA23 Nasal and bronchial airway 7.42E-07 2.33E-01 3.72E-01
Atopic dermatitis EA80 Skin 3.66E-11 4.33E-01 2.24E+00
Autism 6A02 Whole blood 7.37E-01 -4.21E-02 -1.66E-01
Autoimmune uveitis 9A96 Peripheral monocyte 2.05E-04 -1.05E-01 -9.76E-01
Autosomal dominant monocytopenia 4B04 Whole blood 5.76E-01 2.88E-02 1.47E-01
Bacterial infection of gingival 1C1H Gingival tissue 3.32E-02 -5.15E-02 -1.64E-01
Batten disease 5C56.1 Whole blood 7.07E-01 -3.12E-02 -1.94E-01
Behcet's disease 4A62 Peripheral blood 3.72E-01 -2.30E-02 -8.13E-02
Bipolar disorder 6A60-6A6Z Prefrontal cortex 5.52E-01 -1.52E-03 -7.64E-03
Bladder cancer 2C94 Bladder tissue 1.79E-02 3.22E-01 8.51E-01
Breast cancer 2C60-2C6Z Breast tissue 3.82E-09 1.18E-01 2.74E-01
Cardioembolic stroke 8B11.20 Whole blood 6.92E-02 8.89E-02 4.97E-01
Cervical cancer 2C77 Cervical tissue 2.51E-01 -6.42E-02 -1.64E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 2.98E-01 2.88E-02 1.25E-01
Chronic hepatitis C 1E51.1 Whole blood 9.15E-01 -4.17E-02 -2.67E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 2.66E-01 6.97E-02 2.69E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 8.94E-01 2.81E-02 8.28E-02
Chronic rhinosinusitis CA0A Sinus mucosa tissue 1.58E-01 1.77E-01 4.60E-01
Colon cancer 2B90 Colon tissue 7.47E-01 -2.47E-02 -6.32E-02
Coronary artery disease BA80-BA8Z Peripheral blood 4.07E-01 3.22E-01 8.28E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 3.00E-01 2.33E-01 1.04E+00
Endometriosis GA10 Endometrium tissue 7.37E-02 -1.47E-01 -2.91E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 1.88E-01 1.06E-01 4.79E-01
Familial hypercholesterolemia 5C80.00 Whole blood 7.05E-01 1.67E-03 7.43E-03
Gastric cancer 2B72 Gastric tissue 1.62E-01 4.30E-01 1.09E+00
Glioblastopma 2A00.00 Nervous tissue 1.08E-27 -2.56E-01 -8.45E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 5.74E-01 -1.17E-02 -4.90E-02
Head and neck cancer 2D42 Head and neck tissue 2.30E-13 -3.62E-01 -1.18E+00
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 7.16E-01 -1.25E-01 -6.09E-01
Huntington's disease 8A01.10 Whole blood 1.79E-01 5.12E-02 2.22E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 7.26E-01 2.78E-02 3.32E-01
Immunodeficiency 4A00-4A20 Peripheral blood 5.90E-02 3.92E-02 6.68E-01
Influenza 1.00E+30 Whole blood 2.60E-02 3.07E-01 2.88E+00
Interstitial cystitis GC00.3 Bladder tissue 2.14E-03 -4.32E-01 -1.90E+00
Intracranial aneurysm 8B01.0 Intracranial artery 6.35E-01 -1.32E-01 -4.22E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 3.52E-01 -7.54E-02 -2.67E-01
Ischemic stroke 8B11 Peripheral blood 1.58E-01 9.03E-02 6.83E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 1.08E-01 4.12E-02 1.84E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 2.72E-01 -2.90E-01 -5.84E-01
Lateral sclerosis 8B60.4 Skin 3.01E-01 2.00E-01 2.91E+00
Liver cancer 2C12.0 Liver tissue 9.12E-03 -1.96E-01 -3.83E-01
Liver failure DB99.7-DB99.8 Liver tissue 1.35E-02 -8.12E-01 -3.39E+00
Lung cancer 2C25 Lung tissue 4.49E-105 7.58E-01 2.68E+00
Lupus erythematosus 4A40 Whole blood 2.92E-02 -3.51E-02 -7.71E-02
Major depressive disorder 6A70-6A7Z Whole blood 9.66E-02 1.64E-02 7.12E-02
Major depressive disorder 6A70-6A7Z Hippocampus 5.58E-01 6.48E-02 3.25E-01
Melanoma 2C30 Skin 1.46E-03 -5.08E-01 -1.18E+00
Multiple myeloma 2A83.1 Bone marrow 5.56E-04 5.19E-01 2.01E+00
Multiple myeloma 2A83.1 Peripheral blood 7.71E-01 -1.18E-01 -1.70E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 2.30E-01 -8.64E-02 -3.10E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 5.70E-02 -1.07E-01 -3.93E-01
Myelofibrosis 2A20.2 Whole blood 5.06E-01 2.92E-02 2.73E-01
Myocardial infarction BA41-BA50 Peripheral blood 7.00E-02 1.07E-01 3.75E-01
Myopathy 8C70.6 Muscle tissue 5.78E-01 -2.22E-01 -1.27E+00
Neonatal sepsis KA60 Whole blood 7.75E-02 7.46E-02 2.82E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 1.08E-01 -3.07E-01 -9.10E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 4.71E-01 -6.79E-01 -1.09E+00
Obesity related type 2 diabetes 5A11 Omental adipose tissue 2.30E-01 1.30E-01 6.12E-01
Olive pollen allergy CA08.00 Peripheral blood 5.19E-01 2.66E-02 8.72E-02
Oral cancer 2B6E Oral tissue 5.43E-03 -3.10E-01 -6.69E-01
Osteoarthritis FA00-FA0Z Synovial tissue 1.06E-01 -5.16E-01 -1.03E+00
Osteoporosis FB83.1 Bone marrow 5.22E-01 -5.41E-02 -3.29E-01
Ovarian cancer 2C73 Ovarian tissue 1.23E-03 6.59E-01 1.47E+00
Pancreatic cancer 2C10 Pancreas 5.49E-02 -5.64E-01 -1.02E+00
Parkinson's disease 8A00.0 Substantia nigra tissue 2.30E-01 -1.13E-01 -2.91E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 9.16E-01 -2.53E-02 -1.53E-01
Pituitary cancer 2D12 Pituitary tissue 9.43E-05 4.96E-01 1.52E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 3.43E-04 6.16E-01 1.84E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 5.17E-01 3.86E-02 2.03E-01
Polycythemia vera 2A20.4 Whole blood 3.51E-01 -1.45E-02 -1.10E-01
Pompe disease 5C51.3 Biceps muscle 5.05E-01 8.65E-02 5.31E-01
Preterm birth KA21.4Z Myometrium 8.50E-01 -1.23E-01 -3.93E-01
Prostate cancer 2C82 Prostate 6.04E-02 3.25E-01 5.26E-01
Psoriasis EA90 Skin 2.59E-03 7.49E-02 1.90E-01
Rectal cancer 2B92 Rectal colon tissue 1.58E-01 1.03E-01 9.20E-01
Renal cancer 2C90-2C91 Kidney 3.30E-03 -9.44E-01 -1.17E+00
Retinoblastoma 2D02.2 Uvea 2.07E-02 2.75E-01 8.52E-01
Rheumatoid arthritis FA20 Synovial tissue 1.86E-02 -7.22E-01 -1.34E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 1.90E-02 -6.67E-02 -3.65E-01
Schizophrenia 6A20 Prefrontal cortex 8.96E-01 4.99E-02 1.80E-01
Schizophrenia 6A20 Superior temporal cortex 8.43E-01 3.16E-03 1.91E-02
Scleroderma 4A42.Z Whole blood 9.83E-02 1.26E-01 8.23E-01
Seizure 8A60-8A6Z Whole blood 3.58E-01 -1.46E-01 -6.44E-01
Sensitive skin EK0Z Skin 4.06E-01 1.71E-01 5.66E-01
Sepsis with septic shock 1G41 Whole blood 1.42E-01 9.05E-02 3.15E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 1.14E-02 -4.01E-01 -2.20E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 1.60E-01 2.29E-01 7.03E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 9.29E-01 1.76E-01 2.71E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 5.29E-01 1.26E-02 4.06E-02
Skin cancer 2C30-2C3Z Skin 1.16E-12 -3.47E-01 -8.80E-01
Thrombocythemia 3B63 Whole blood 5.82E-01 -2.32E-02 -1.97E-01
Thrombocytopenia 3B64 Whole blood 4.58E-01 3.99E-01 9.69E-01
Thyroid cancer 2D10 Thyroid 9.99E-01 -6.60E-02 -2.15E-01
Tibial muscular dystrophy 8C75 Muscle tissue 7.52E-04 -3.35E-01 -1.71E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 5.76E-01 -7.63E-02 -3.34E-01
Type 2 diabetes 5A11 Liver tissue 3.67E-01 -1.47E-02 -2.89E-02
Ureter cancer 2C92 Urothelium 5.31E-01 -8.34E-03 -3.34E-02
Uterine cancer 2C78 Endometrium tissue 1.35E-01 2.06E-02 2.81E-02
Vitiligo ED63.0 Skin 7.15E-01 -6.79E-02 -3.99E-01
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⏷ Show the Full List of Expression Under 107 Diseases

References

1 SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency. Hum Mol Genet. 2018 Feb 1;27(3):499-504.