Details of the Drug

General Information of Drug (ID: DMUXQG7)

Drug Name
Phosphate
Synonyms
orthophosphate; Phosphate ion; 14265-44-2; O-Phosphate; UNII-NK08V8K8HR; NK08V8K8HR; Phosphates; Phosphate ions; PO4; a phosphate group; tetraoxophosphate(V); tetraoxophosphate(3-); Phosphoric acid trianion; tetraoxidophosphate(3-); phosphoric acid, ion(3-); AC1L1AN2; DTXSID7039672; CHEBI:18367; CTK0H5978; NBIIXXVUZAFLBC-UHFFFAOYSA-K; BDBM50155537; AKOS015903596; PO4(3-); CREATINE PHOSPHATE; N-PHOSPHOCREATINE; [PO4](3-); I14-18227
Indication
Disease Entry ICD 11 Status REF
Constipation DD91.1 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 94.971
Logarithm of the Partition Coefficient (xlogp) -2.3
Rotatable Bond Count (rotbonds) 0
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
O4P-3
IUPAC Name
phosphate
Canonical SMILES
[O-]P(=O)([O-])[O-]
InChI
InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKey
NBIIXXVUZAFLBC-UHFFFAOYSA-K
Cross-matching ID
PubChem CID
1061
ChEBI ID
CHEBI:18367
CAS Number
14265-44-2
TTD ID
D08VYC
VARIDT ID
DR00132
INTEDE ID
DR2121

Molecular Interaction Atlas of This Drug


Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Mitochondrial dicarboxylate carrier (SLC25A10) DTJYKDQ DIC_HUMAN Substrate [2]
Phosphate carrier protein (SLC25A3) DTCRIWV MPCP_HUMAN Substrate [3]
Calcium-binding mitochondrial carrier protein SCaMC-3 (SLC25A23) DTLQ0EZ SCMC3_HUMAN Substrate [4]
Sodium-dependent phosphate transporter 2 (SLC20A2) DTFD4VB S20A2_HUMAN Substrate [5]
Sodium-dependent phosphate transporter 1 (SLC20A1) DTMULXV S20A1_HUMAN Substrate [5]
Vesicular glutamate transporter 1 (SLC17A7) DTNK0FR VGLU1_HUMAN Substrate [6]
Vesicular glutamate transporter 2 (SLC17A6) DT5LHCR VGLU2_HUMAN Substrate [7]
Calcium-binding mitochondrial carrier protein SCaMC-2 (SLC25A25) DTN7X5J SCMC2_HUMAN Substrate [8]
Calcium-binding mitochondrial carrier protein SCaMC-1 (SLC25A24) DTVAEDK SCMC1_HUMAN Substrate [9]
Glycerol-3-phosphate permease (SLC37A1) DTH9SQJ G6PT2_HUMAN Substrate [10]
Probable small intestine urate exporter (SLC17A4) DTHE530 S17A4_HUMAN Substrate [11]
Sodium-dependent phosphate transport protein 4 (SLC17A3) DTFOJL7 NPT4_HUMAN Substrate [12]
Sodium-dependent phosphate transport protein 1 (SLC17A1) DT8ARWJ NPT1_HUMAN Substrate [7]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
GDP-D-glucose phosphorylase 1 (GDPGP1)
Main DME 		DE9P5K7 GDPP1_HUMAN Substrate [13]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bone morphogenetic protein 2 (BMP2) OT23T37S BMP2_HUMAN Gene/Protein Processing [14]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Protein Interaction/Cellular Processes [15]
Dentin matrix acidic phosphoprotein 1 (DMP1) OTBWBWW7 DMP1_HUMAN Gene/Protein Processing [16]
Fibroblast growth factor 23 (FGF23) OTZT523D FGF23_HUMAN Gene/Protein Processing [17]
Growth arrest-specific protein 6 (GAS6) OTPOPUUE GAS6_HUMAN Gene/Protein Processing [18]
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) OTGBRJDQ MKNK1_HUMAN Gene/Protein Processing [19]
Matrix extracellular phosphoglycoprotein (MEPE) OTXJRUW0 MEPE_HUMAN Regulation of Drug Effects [20]
Parathyroid hormone (PTH) OTD721UF PTHY_HUMAN Gene/Protein Processing [21]
Phosphate-regulating neutral endopeptidase PHEX (PHEX) OTG7N3J7 PHEX_HUMAN Gene/Protein Processing [17]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Gene/Protein Processing [15]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency. Hum Mol Genet. 2018 Feb 1;27(3):499-504.
3 The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome c oxidase biogenesis. J Biol Chem. 2018 Feb 9;293(6):1887-1896.
4 Cellular expression and alternative splicing of SLC25A23, a member of the mitochondrial Ca2+-dependent solute carrier gene family. Gene. 2005 Jan 31;345(2):173-82.
5 Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50.
6 SLC17: a functionally diverse family of organic anion transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):350-9.
7 Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter. J Biol Chem. 2010 Aug 20;285(34):26107-13.
8 Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway that might be involved in muscle thermogenesis. Sci Rep. 2017 Jun 6;7(1):2885.
9 De Novo Mutations in SLC25A24 Cause a Disorder Characterized by Early Aging, Bone Dysplasia, Characteristic Face, and Early Demise. Am J Hum Genet. 2017 Nov 2;101(5):844-855.
10 SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. PLoS One. 2011;6(9):e23157.
11 A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60.
12 Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem. 2010 Nov 5;285(45):35123-32.
13 A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. J Biol Chem. 2011 Jun 17;286(24):21511-23.
14 Menaquinone-4 Accelerates Calcification of Human Aortic Valve Interstitial Cells in High-Phosphate Medium through PXR. J Pharmacol Exp Ther. 2020 Mar;372(3):277-284. doi: 10.1124/jpet.119.263160. Epub 2019 Dec 16.
15 High expression of the Pi-transporter SLC20A1/Pit1 in calcific aortic valve disease promotes mineralization through regulation of Akt-1. PLoS One. 2013;8(1):e53393. doi: 10.1371/journal.pone.0053393. Epub 2013 Jan 4.
16 Inorganic phosphate stimulates DMP1 expression in human periodontal ligament fibroblasts embedded in three-dimensional collagen gels. Cells Tissues Organs. 2010;192(2):116-24. doi: 10.1159/000289585. Epub 2010 Feb 24.
17 Bone as a source of FGF23: regulation by phosphate?. Bone. 2004 Nov;35(5):1192-9. doi: 10.1016/j.bone.2004.06.014.
18 Androgen receptor-dependent transactivation of growth arrest-specific gene 6 mediates inhibitory effects of testosterone on vascular calcification. J Biol Chem. 2010 Mar 5;285(10):7537-44. doi: 10.1074/jbc.M109.055087. Epub 2010 Jan 4.
19 Elevated inorganic phosphate stimulates Akt-ERK1/2-Mnk1 signaling in human lung cells. Am J Respir Cell Mol Biol. 2006 Nov;35(5):528-39. doi: 10.1165/rcmb.2005-0477OC. Epub 2006 Jun 8.
20 Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density. J Clin Endocrinol Metab. 2004 Aug;89(8):4158-61. doi: 10.1210/jc.2003-032031.
21 Calcimimetics as an adjuvant treatment for familial hypophosphatemic rickets. Clin J Am Soc Nephrol. 2008 May;3(3):658-64. doi: 10.2215/CJN.04981107. Epub 2008 Feb 6.