Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTLWPXS)

DTP Name Zinc transporter ZIP1 (SLC39A1)
Gene Name SLC39A1
UniProt ID
Q9NY26 (S39A1_HUMAN)
VARIDT ID
DTD0337
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms IRT1; SLC39A1; Solute carrier family 39 member 1; ZIP-1; ZIP1; ZIRTL; Zinc transporter ZIP1; Zinc-iron-regulated transporter-like; hZIP1
DTP Family Zinc (Zn(2+))-Iron (Fe(2+)) Permease (ZIP) Family ;
Tissue Specificity Ubiquitous. Expressed in most adult and fetaltissues including the epidermis.
Sequence
MGPWGEPELLVWRPEAVASEPPVPVGLEVKLGALVLLLVLTLLCSLVPICVLRRPGANHE
GSASRQKALSLVSCFAGGVFLATCLLDLLPDYLAAIDEALAALHVTLQFPLQEFILAMGF
FLVLVMEQITLAYKEQSGPSPLEETRALLGTVNGGPQHWHDGPGVPQASGAPATPSALRA
CVLVFSLALHSVFEGLAVGLQRDRARAMELCLALLLHKGILAVSLSLRLLQSHLRAQVVA
GCGILFSCMTPLGIGLGAALAESAGPLHQLAQSVLEGMAAGTFLYITFLEILPQELASSE
QRILKVILLLAGFALLTGLLFIQI
Function
This transporter mediates zinc uptake, and responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells. May function as a major endogenous zinc uptake transporter in many cells of the body.
Endogenous Substrate(s) Zn2+
TCDB ID
2.A.5.3.2
Gene ID
27173
KEGG Pathway
Alzheimer disease (hsa05010 )
Parkinson disease (hsa05012 )
Reactome Pathway
Zinc influx into cells by the SLC39 gene family (R-HSA-442380 )

Molecular Interaction Atlas (MIA) of This DTP

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTP
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zinc salts DMZ4R3Q Arthritis FA20 Approved [1]
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Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 1.53E-33 3.52E-01 1.46E+00
Adrenocortical carcinoma 2D11.Z Kidney 9.37E-01 4.13E-02 1.34E-01
Alopecia ED70 Skin from scalp 2.79E-03 -8.77E-02 -5.38E-01
Alzheimer's disease 8A20 Entorhinal cortex 1.02E-05 7.52E-02 3.66E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 2.15E-01 2.29E-01 6.36E-01
Aortic stenosis BB70 Calcified aortic valve 6.67E-01 1.46E-01 2.86E-01
Apnea 7A40 Hyperplastic tonsil 2.90E-01 -1.16E-01 -6.65E-01
Arthropathy FA00-FA5Z Peripheral blood 9.89E-01 1.43E-03 3.16E-03
Asthma CA23 Nasal and bronchial airway 9.44E-04 9.66E-02 1.85E-01
Atopic dermatitis EA80 Skin 5.62E-01 1.66E-02 6.73E-02
Autism 6A02 Whole blood 8.94E-02 -1.09E-01 -3.12E-01
Autoimmune uveitis 9A96 Peripheral monocyte 7.57E-01 7.53E-02 6.55E-01
Autosomal dominant monocytopenia 4B04 Whole blood 1.70E-01 -5.19E-01 -1.40E+00
Bacterial infection of gingival 1C1H Gingival tissue 5.79E-06 2.01E-01 8.19E-01
Batten disease 5C56.1 Whole blood 6.07E-01 4.94E-02 2.44E-01
Behcet's disease 4A62 Peripheral blood 8.89E-01 9.96E-03 5.10E-02
Bipolar disorder 6A60-6A6Z Prefrontal cortex 2.53E-01 -9.96E-02 -3.34E-01
Bladder cancer 2C94 Bladder tissue 1.25E-01 6.98E-02 2.30E-01
Breast cancer 2C60-2C6Z Breast tissue 5.03E-37 3.26E-01 1.06E+00
Cardioembolic stroke 8B11.20 Whole blood 1.10E-02 1.72E-01 7.07E-01
Cervical cancer 2C77 Cervical tissue 7.52E-04 3.19E-01 1.00E+00
Childhood onset rheumatic disease FA20.Z Peripheral blood 9.60E-01 9.93E-02 2.08E-01
Chronic hepatitis C 1E51.1 Whole blood 4.61E-01 2.53E-02 1.95E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 4.29E-01 -1.53E-02 -4.31E-02
Chronic obstructive pulmonary disease CA22 Small airway epithelium 6.78E-01 3.29E-02 1.18E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 9.08E-02 1.54E-01 5.98E-01
Colon cancer 2B90 Colon tissue 1.70E-01 1.89E-02 6.64E-02
Coronary artery disease BA80-BA8Z Peripheral blood 3.06E-01 -1.53E-01 -4.92E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 4.71E-01 1.95E-02 7.34E-02
Endometriosis GA10 Endometrium tissue 3.09E-02 1.52E-01 5.99E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 7.22E-01 -3.68E-02 -1.93E-01
Familial hypercholesterolemia 5C80.00 Whole blood 2.56E-01 -2.13E-02 -1.02E-01
Gastric cancer 2B72 Gastric tissue 1.35E-02 4.34E-01 3.79E+00
Glioblastopma 2A00.00 Nervous tissue 1.26E-119 6.74E-01 1.83E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.44E-02 6.83E-01 1.33E+00
Head and neck cancer 2D42 Head and neck tissue 5.82E-20 3.88E-01 1.47E+00
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 1.03E-01 5.31E-02 3.61E-01
Huntington's disease 8A01.10 Whole blood 7.01E-01 4.29E-02 1.81E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 3.13E-02 -9.37E-02 -1.05E+00
Immunodeficiency 4A00-4A20 Peripheral blood 1.64E-04 2.37E-01 2.44E+00
Influenza 1.00E+30 Whole blood 4.80E-03 -1.01E+00 -4.05E+00
Interstitial cystitis GC00.3 Bladder tissue 2.79E-01 9.90E-02 6.83E-01
Intracranial aneurysm 8B01.0 Intracranial artery 2.50E-05 3.98E-01 1.91E+00
Irritable bowel syndrome DD91.0 Rectal colon tissue 9.97E-03 -1.08E-01 -4.21E-01
Ischemic stroke 8B11 Peripheral blood 3.86E-01 1.48E-01 5.40E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 1.90E-01 -2.64E-01 -3.95E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 3.28E-01 4.37E-02 1.37E-01
Lateral sclerosis 8B60.4 Skin 8.28E-01 -1.17E-02 -1.71E-01
Liver cancer 2C12.0 Liver tissue 1.05E-08 4.90E-01 1.24E+00
Liver failure DB99.7-DB99.8 Liver tissue 4.12E-01 4.89E-02 1.28E-01
Lung cancer 2C25 Lung tissue 2.14E-04 4.82E-02 1.68E-01
Lupus erythematosus 4A40 Whole blood 2.70E-01 2.06E-02 4.31E-02
Major depressive disorder 6A70-6A7Z Whole blood 6.01E-01 -2.03E-02 -6.44E-02
Major depressive disorder 6A70-6A7Z Hippocampus 8.85E-01 -3.09E-02 -1.01E-01
Melanoma 2C30 Skin 3.74E-03 2.46E-01 4.44E-01
Multiple myeloma 2A83.1 Bone marrow 5.27E-01 7.84E-02 2.74E-01
Multiple myeloma 2A83.1 Peripheral blood 5.61E-01 -6.09E-02 -1.32E-01
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 8.96E-02 -1.71E-01 -5.40E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 1.68E-01 1.81E-01 5.02E-01
Myelofibrosis 2A20.2 Whole blood 8.74E-04 -2.87E-01 -2.55E+00
Myocardial infarction BA41-BA50 Peripheral blood 4.29E-01 2.40E-01 4.35E-01
Myopathy 8C70.6 Muscle tissue 1.28E-01 -8.19E-02 -3.01E-01
Neonatal sepsis KA60 Whole blood 1.68E-01 6.46E-02 1.89E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 6.45E-03 3.07E-01 1.04E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 7.06E-01 -3.31E-02 -1.29E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 4.84E-03 -2.11E-01 -2.20E+00
Olive pollen allergy CA08.00 Peripheral blood 2.20E-02 3.63E-01 1.92E+00
Oral cancer 2B6E Oral tissue 7.41E-01 -6.47E-04 -2.09E-03
Osteoarthritis FA00-FA0Z Synovial tissue 1.49E-01 3.06E-01 4.24E-01
Osteoporosis FB83.1 Bone marrow 2.11E-01 7.58E-02 1.33E-01
Ovarian cancer 2C73 Ovarian tissue 1.33E-02 6.17E-01 1.64E+00
Pancreatic cancer 2C10 Pancreas 2.30E-06 6.73E-01 1.72E+00
Parkinson's disease 8A00.0 Substantia nigra tissue 3.05E-01 3.25E-03 9.07E-03
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 1.52E-06 3.72E-01 2.21E+00
Pituitary cancer 2D12 Pituitary tissue 3.47E-01 -5.21E-02 -1.98E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 6.24E-02 -1.36E-01 -5.13E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 2.04E-01 3.60E-02 3.42E-01
Polycythemia vera 2A20.4 Whole blood 4.66E-02 4.46E-02 3.38E-01
Pompe disease 5C51.3 Biceps muscle 4.05E-05 5.17E-01 4.10E+00
Preterm birth KA21.4Z Myometrium 6.42E-01 -3.12E-02 -3.03E-01
Prostate cancer 2C82 Prostate 6.23E-08 -5.37E-01 -1.63E+00
Psoriasis EA90 Skin 2.30E-01 -5.06E-02 -1.36E-01
Rectal cancer 2B92 Rectal colon tissue 1.63E-01 -3.33E-02 -1.30E-01
Renal cancer 2C90-2C91 Kidney 3.68E-02 3.08E-01 8.12E-01
Retinoblastoma 2D02.2 Uvea 3.88E-09 1.03E+00 5.14E+00
Rheumatoid arthritis FA20 Synovial tissue 1.56E-05 1.09E+00 3.94E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 9.60E-01 -1.75E-02 -1.14E-01
Schizophrenia 6A20 Prefrontal cortex 1.15E-02 1.64E-01 4.29E-01
Schizophrenia 6A20 Superior temporal cortex 5.23E-01 1.00E-01 5.59E-01
Scleroderma 4A42.Z Whole blood 6.56E-02 -9.75E-02 -4.75E-01
Seizure 8A60-8A6Z Whole blood 9.40E-01 3.11E-02 9.77E-02
Sensitive skin EK0Z Skin 9.59E-01 9.83E-03 9.53E-02
Sepsis with septic shock 1G41 Whole blood 3.86E-27 2.87E-01 9.60E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 1.15E-01 7.76E-02 4.27E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 3.26E-01 9.33E-02 6.95E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 6.54E-01 -1.26E-01 -3.77E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 9.22E-01 -1.04E-01 -7.92E-01
Skin cancer 2C30-2C3Z Skin 7.23E-06 9.71E-02 2.77E-01
Thrombocythemia 3B63 Whole blood 8.38E-01 1.64E-02 1.41E-01
Thrombocytopenia 3B64 Whole blood 7.26E-01 2.64E-01 4.20E-01
Thyroid cancer 2D10 Thyroid 3.04E-03 -1.05E-01 -3.79E-01
Tibial muscular dystrophy 8C75 Muscle tissue 6.11E-03 1.86E-01 4.97E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 5.49E-02 4.38E-01 3.16E+00
Type 2 diabetes 5A11 Liver tissue 1.19E-01 2.40E-01 9.75E-01
Ureter cancer 2C92 Urothelium 9.65E-01 4.65E-02 3.53E-01
Uterine cancer 2C78 Endometrium tissue 2.66E-03 6.78E-03 1.14E-02
Vitiligo ED63.0 Skin 6.55E-01 1.32E-01 5.94E-01
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⏷ Show the Full List of Expression Under 107 Diseases

References

1 SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms. Biochem J. 2016 May 1;473(9):1113-24.