Details of the Drug Transporter (DTP)

General Information of Drug Transporter (DTP) (ID: DTNYBG7)

DTP Name Mitochondrial uncoupling protein 2 (SLC25A8)
Gene Name SLC25A8
UniProt ID
P55851 (UCP2_HUMAN)
VARIDT ID
DTD0225
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Synonyms BMIQ4; SLC25A8; Solute carrier family 25 member 8; UCP 2; UCP2; UCPH
DTP Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Widely expressed in adult human tissues,including tissues rich in macrophages. Most expressed in whiteadipose tissue and skeletal muscle.
Sequence
MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYR
GVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRL
LAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTS
PNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKT
RYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMA
ACTSREAPF
Function
This transporter is mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
Endogenous Substrate(s) H+; Cl-
TCDB ID
2.A.29.3.4
Gene ID
7351
Reactome Pathway
The proton buffering model (R-HSA-167827 )
The fatty acid cycling model (R-HSA-167826 )

Molecular Expression Atlas (MEA) of This DTP

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DTP
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 9.05E-06 -1.27E-01 -2.47E-01
Adrenocortical carcinoma 2D11.Z Kidney 8.77E-03 -2.72E-01 -4.99E-01
Alopecia ED70 Skin from scalp 5.09E-01 -3.74E-03 -8.21E-03
Alzheimer's disease 8A20 Entorhinal cortex 1.06E-02 2.02E-01 3.67E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 3.73E-01 1.66E-01 6.13E-01
Aortic stenosis BB70 Calcified aortic valve 7.97E-02 3.93E-01 1.01E+00
Apnea 7A40 Hyperplastic tonsil 1.23E-01 1.53E+00 2.62E+00
Arthropathy FA00-FA5Z Peripheral blood 1.47E-01 -1.26E-01 -5.85E-01
Asthma CA23 Nasal and bronchial airway 8.37E-01 2.75E-02 6.75E-02
Atopic dermatitis EA80 Skin 3.81E-02 5.22E-02 1.29E-01
Autism 6A02 Whole blood 6.48E-04 -2.52E-01 -5.89E-01
Autoimmune uveitis 9A96 Peripheral monocyte 7.38E-01 2.14E-01 6.19E-01
Autosomal dominant monocytopenia 4B04 Whole blood 2.02E-01 -7.61E-01 -1.21E+00
Bacterial infection of gingival 1C1H Gingival tissue 7.85E-18 9.14E-01 1.56E+00
Batten disease 5C56.1 Whole blood 9.84E-01 2.57E-02 1.39E-01
Behcet's disease 4A62 Peripheral blood 4.95E-01 1.17E-01 3.66E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 5.46E-01 -9.24E-02 -3.24E-01
Bladder cancer 2C94 Bladder tissue 9.39E-01 1.22E-01 2.15E-01
Breast cancer 2C60-2C6Z Breast tissue 3.93E-20 5.19E-01 7.21E-01
Cardioembolic stroke 8B11.20 Whole blood 8.99E-01 -1.49E-02 -6.64E-02
Cervical cancer 2C77 Cervical tissue 1.94E-05 1.05E+00 1.57E+00
Childhood onset rheumatic disease FA20.Z Peripheral blood 3.39E-01 1.31E-01 1.39E-01
Chronic hepatitis C 1E51.1 Whole blood 5.53E-01 -2.17E-01 -4.08E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 6.15E-02 -3.00E-01 -5.54E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 3.21E-01 -6.71E-02 -1.20E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 4.20E-01 3.30E-01 4.43E-01
Colon cancer 2B90 Colon tissue 8.57E-05 -2.30E-01 -3.75E-01
Coronary artery disease BA80-BA8Z Peripheral blood 6.77E-01 -1.21E-01 -3.04E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 6.81E-01 1.18E-02 2.27E-02
Endometriosis GA10 Endometrium tissue 6.85E-01 3.30E-01 2.44E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 7.89E-01 -5.23E-02 -1.53E-01
Familial hypercholesterolemia 5C80.00 Whole blood 1.31E-03 5.26E-01 1.69E+00
Gastric cancer 2B72 Gastric tissue 3.11E-01 5.99E-01 6.16E-01
Glioblastopma 2A00.00 Nervous tissue 2.82E-99 9.89E-01 1.52E+00
Glioma 2A00.0Y-2A00.0Z White matter tissue 5.58E-01 -2.34E-01 -1.53E-01
Head and neck cancer 2D42 Head and neck tissue 2.20E-09 -1.63E+00 -8.52E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 2.08E-01 1.17E-01 2.96E-01
Huntington's disease 8A01.10 Whole blood 5.11E-01 -4.82E-02 -2.55E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 1.03E-02 1.18E+00 2.04E+00
Immunodeficiency 4A00-4A20 Peripheral blood 7.04E-02 5.95E-02 3.87E-01
Influenza 1.00E+30 Whole blood 1.07E-02 -1.42E+00 -3.45E+00
Interstitial cystitis GC00.3 Bladder tissue 3.24E-01 4.42E-01 8.82E-01
Intracranial aneurysm 8B01.0 Intracranial artery 1.12E-02 1.55E+00 2.74E+00
Irritable bowel syndrome DD91.0 Rectal colon tissue 3.71E-01 -8.85E-02 -1.91E-01
Ischemic stroke 8B11 Peripheral blood 8.96E-02 -1.94E-01 -8.59E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 1.81E-05 -4.36E-01 -9.09E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 1.97E-01 4.75E-01 8.51E-01
Lateral sclerosis 8B60.4 Skin 3.36E-02 1.58E-01 1.13E+00
Liver cancer 2C12.0 Liver tissue 2.39E-01 -4.94E-02 -1.13E-01
Liver failure DB99.7-DB99.8 Liver tissue 1.43E-07 2.52E+00 4.45E+00
Lung cancer 2C25 Lung tissue 3.82E-02 -6.56E-02 -1.07E-01
Lupus erythematosus 4A40 Whole blood 7.52E-01 -6.54E-02 -1.01E-01
Major depressive disorder 6A70-6A7Z Whole blood 2.11E-01 -1.34E-01 -4.67E-01
Major depressive disorder 6A70-6A7Z Hippocampus 8.36E-01 4.35E-02 1.59E-01
Melanoma 2C30 Skin 2.72E-02 3.92E-01 4.08E-01
Multiple myeloma 2A83.1 Bone marrow 7.72E-01 2.08E-01 4.68E-01
Multiple myeloma 2A83.1 Peripheral blood 4.54E-01 3.81E-02 6.53E-02
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 8.16E-01 1.16E-01 4.51E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 7.43E-01 4.12E-02 9.52E-02
Myelofibrosis 2A20.2 Whole blood 4.25E-02 -1.79E-01 -8.38E-01
Myocardial infarction BA41-BA50 Peripheral blood 3.10E-02 -5.23E-01 -9.10E-01
Myopathy 8C70.6 Muscle tissue 2.95E-02 5.70E-01 8.56E-01
Neonatal sepsis KA60 Whole blood 3.03E-05 -2.77E-01 -5.35E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 1.21E-02 -5.08E-01 -1.16E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 4.39E-01 4.90E-01 8.78E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 9.36E-02 3.49E-01 1.09E+00
Olive pollen allergy CA08.00 Peripheral blood 9.47E-01 -4.25E-02 -7.51E-02
Oral cancer 2B6E Oral tissue 8.48E-01 1.60E-01 1.70E-01
Osteoarthritis FA00-FA0Z Synovial tissue 7.27E-01 -9.45E-02 -1.28E-01
Osteoporosis FB83.1 Bone marrow 5.22E-01 -2.37E-03 -2.09E-03
Ovarian cancer 2C73 Ovarian tissue 4.11E-04 3.36E+00 2.16E+00
Pancreatic cancer 2C10 Pancreas 2.60E-01 6.79E-01 5.06E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 3.97E-01 3.40E-01 8.98E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 7.84E-02 -7.15E-02 -2.96E-01
Pituitary cancer 2D12 Pituitary tissue 3.37E-01 3.65E-01 7.57E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 9.75E-01 2.09E-01 4.74E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 1.78E-01 -2.21E-01 -1.12E+00
Polycythemia vera 2A20.4 Whole blood 3.37E-14 -4.45E-01 -2.06E+00
Pompe disease 5C51.3 Biceps muscle 1.68E-05 1.54E+00 2.95E+00
Preterm birth KA21.4Z Myometrium 8.95E-01 -2.14E-02 -5.14E-02
Prostate cancer 2C82 Prostate 3.24E-05 -6.74E-01 -1.02E+00
Psoriasis EA90 Skin 9.01E-01 -4.73E-02 -7.55E-02
Rectal cancer 2B92 Rectal colon tissue 6.49E-02 -2.45E-01 -6.81E-01
Renal cancer 2C90-2C91 Kidney 6.49E-01 5.35E-02 8.03E-02
Retinoblastoma 2D02.2 Uvea 3.58E-02 1.07E+00 3.39E+00
Rheumatoid arthritis FA20 Synovial tissue 1.06E-01 1.03E+00 5.03E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 3.36E-01 -1.18E-01 -3.13E-01
Schizophrenia 6A20 Prefrontal cortex 8.35E-02 2.25E-01 1.02E-01
Schizophrenia 6A20 Superior temporal cortex 1.92E-02 3.35E-01 1.12E+00
Scleroderma 4A42.Z Whole blood 4.85E-06 -4.65E-01 -2.80E+00
Seizure 8A60-8A6Z Whole blood 1.69E-01 -1.39E-01 -2.37E-01
Sensitive skin EK0Z Skin 5.00E-01 5.26E-02 2.79E-01
Sepsis with septic shock 1G41 Whole blood 1.07E-19 -4.60E-01 -8.78E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 3.26E-01 4.10E-01 1.88E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 8.68E-03 4.85E-01 1.58E+00
Simpson golabi behmel syndrome LD2C Adipose tissue 8.47E-01 -1.27E-02 -3.20E-02
Sjogren's syndrome 4A43.2 Salivary gland tissue 7.49E-03 3.13E-01 1.49E+00
Skin cancer 2C30-2C3Z Skin 5.92E-05 3.31E-01 5.18E-01
Thrombocythemia 3B63 Whole blood 2.30E-06 -4.39E-01 -2.06E+00
Thrombocytopenia 3B64 Whole blood 5.10E-01 2.79E-01 4.57E-01
Thyroid cancer 2D10 Thyroid 2.94E-05 4.55E-01 6.33E-01
Tibial muscular dystrophy 8C75 Muscle tissue 5.44E-09 1.54E+00 2.61E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 3.81E-03 1.23E+00 3.84E+00
Type 2 diabetes 5A11 Liver tissue 5.53E-01 2.81E-01 7.84E-01
Ureter cancer 2C92 Urothelium 9.82E-01 5.68E-02 7.17E-02
Uterine cancer 2C78 Endometrium tissue 4.06E-03 -2.17E-01 -1.54E-01
Vitiligo ED63.0 Skin 4.39E-01 -7.40E-02 -1.85E-01
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⏷ Show the Full List of Expression Under 107 Diseases

The Drug Therapeutic Target (DTT) Role of This DTP

DTP DTT Name Mitochondrial uncoupling protein 2 (UCP2) DTT Info
DTP DTT Type Clinical trial
1 Clinical Trial Drug(s) Targeting This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
CL-316,243 DMXH1KC Obesity 5B81 Phase 2 [1]
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1 Investigative Drug(s) Targeting This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
NC-2100 DMJKZUC Discovery agent N.A. Investigative [2]
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References

1 Anti-obesity and anti-diabetic effects of CL316,243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur J Endocrinol. 1997 Apr;136(4):429-37.
2 A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes. 2000 May;49(5):759-67.