Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT13TL0)

DTT Name Interferon gamma receptor (IFNGR2)
Synonyms
Interferon gamma transducer 1; Interferon gamma receptor beta-chain; Interferon gamma receptor accessory factor 1; Interferon gamma receptor 2; IFNGT1; IFNGR; IFN-gamma-R2; IFN-gamma-R-beta; IFN-gamma-R; IFN-gamma receptor 2; CDw119; CD119; AF-1
Gene Name IFNGR2
DTT Type
Successful target
 [1]
BioChemical Class
Cytokine receptor
UniProt ID
INGR2_HUMAN
TTD ID
T30284
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRPTLLWSLLLLLGVFAAAAAAPPDPLSQLPAPQHPKIRLYNAEQVLSWEPVALSNSTRP
VVYQVQFKYTDSKWFTADIMSIGVNCTQITATECDFTAASPSAGFPMDFNVTLRLRAELG
ALHSAWVTMPWFQHYRNVTVGPPENIEVTPGEGSLIIRFSSPFDIADTSTAFFCYYVHYW
EKGGIQQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMAD
ASTELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQ
PILEALDKDSSPKDDVWDSVSIISFPEKEQEDVLQTL
Function
Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required for signal transduction in contrast to other receptor subunit responsible for ligand binding. Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (, ,).
KEGG Pathway
Cytokine-cytokine receptor interaction (hsa04060 )
HIF-1 signaling pathway (hsa04066 )
Osteoclast differentiation (hsa04380 )
Jak-STAT signaling pathway (hsa04630 )
Natural killer cell mediated cytotoxicity (hsa04650 )
Salmonella infection (hsa05132 )
Leishmaniasis (hsa05140 )
Chagas disease (American trypanosomiasis) (hsa05142 )
Toxoplasmosis (hsa05145 )
Tuberculosis (hsa05152 )
Measles (hsa05162 )
Influenza A (hsa05164 )
Herpes simplex infection (hsa05168 )
Inflammatory bowel disease (IBD) (hsa05321 )
Reactome Pathway
Regulation of IFNG signaling (R-HSA-877312 )
Interferon gamma signaling (R-HSA-877300 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Anifrolumab DM3FPAQ Systemic lupus erythematosus 4A40.0 Approved [2]
Interferon gamma-1b DMWUMRL Chronic granulomatous disease 4A00.0Y Approved [1]
------------------------------------------------------------------------------------

References

1 Genetic polymorphisms in the promoter of the interferon gamma receptor 1 gene are associated with atopic cataracts. Invest Ophthalmol Vis Sci. 2007 Feb;48(2):583-9.
2 FDA Approved Drug Products from FDA Official Website. 2021. Application Number: 761123.