General Information of Drug Therapeutic Target (DTT) (ID: TT27K59)

DTT Name Platelet activating factor (PAF)
Synonyms PAF
Gene Name PAF
DTT Type
Literature-reported target
[1]
UniProt ID
NOUNIPROTAC
TTD ID
T67046

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Preclinical Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indol-3-carbinol DMXJO20 Fungal infection 1F29-1F2F Preclinical [1]
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3 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
F-0401 DMR1X2U N. A. N. A. Terminated [2]
SRI 63-441 DMMPSY2 N. A. N. A. Terminated [3]
UR-12670 DM7F94W N. A. N. A. Terminated [4]
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1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
SCH 44643 DMNLD6W Discovery agent N.A. Investigative [5]
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References

1 Pinusolide from the leaves of Biota orientalis as potent platelet activating factor antagonist. Planta Med. 1999 Feb;65(1):39-42.
2 Protective effects of a novel calcium antagonist with platelet-activating factor-antagonistic action, F-0401, against ischemic brain damage. Arch Int Pharmacodyn Ther. 1994 May-Jun;327(3):266-78.
3 Pharmacologic modulation of experimental postischemic hepatic function. Ann Surg. 1989 Feb;209(2):200-10.
4 Long-term protective effect of UR-12670 after warm renal ischemia in uninephrectomized rats. Kidney Int. 1999 Nov;56(5):1798-808.
5 Determination of plasma concentrations of SCH 44643 by a GC method and correlation of plasma concentration and anti-PAF activity in cynomolgus monkeys. J Pharm Biomed Anal. 1996 Dec;15(3):343-7.