| DTT Name |
HUMAN toll-like receptor 9 (TLR9)
|
| Synonyms |
UNQ5798/PRO19605; TLR-9; CD289 |
| Gene Name |
TLR9
|
| BioChemical Class |
Toll-like receptor
|
| UniProt ID |
|
| TTD ID |
|
| 3D Structure |
|
| Sequence |
MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAA
PRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFL
AVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY
KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDL
ANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLN
ASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSF
GSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV
DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLS
RNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHS
FTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSL
RALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRL
RDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGF
FSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAA
VPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCG
WDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRG
RWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLE
DRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHF
YNRNFCQGPTAE
|
| Function |
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.
|
| KEGG Pathway |
- Toll-like receptor signaling pathway (hsa04620 )
- Salmonella infection (hsa05132 )
- Chagas disease (hsa05142 )
- African trypanosomiasis (hsa05143 )
- Malaria (hsa05144 )
- Tuberculosis (hsa05152 )
- Measles (hsa05162 )
- Herpes simplex virus 1 infection (hsa05168 )
- PD-L1 expression and PD-1 checkpoint pathway in cancer (hsa05235 )
|
| Reactome Pathway |
- Trafficking and processing of endosomal TLR (R-HSA-1679131 )
- Toll Like Receptor 9 (TLR9) Cascade (R-HSA-168138 )
- Potential therapeutics for SARS (R-HSA-9679191 )
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (R-HSA-975110 )
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (R-HSA-975138 )
- MyD88 dependent cascade initiated on endosome (R-HSA-975155 )
- PI3K Cascade (R-HSA-109704 )
|
|
|
|
|
|
|
