Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT4LRUE)

• DTT Name: HUMAN solute carrier family 6 member 15 (SLC6A15)
• Synonyms: Transporter v7-3; Sodium-dependent neutral amino acid transporter B(0)AT2; Sodium-coupled branched-chain amino-acid transporter 1; Sodium- and chloride-dependent neurotransmitter transporter NTT73
• Gene Name: SLC6A15
• BioChemical Class: SLC6A15 subfamily
• UniProt ID: S6A15_HUMAN
• TTD ID: T01138
• Sequence:
  MPKNSKVVKRELDDDVTESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDE
  RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS
  VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD
  QCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVC
  LAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWR
  EAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKA
  NVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPA
  LHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIE
  GIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILE
  NIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYN
  AWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDDSSGNLASVTYKRG
  RVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMAD
  IMPDMPESDL
• Function: Human protein solute carrier family 6 member 15 interacts with SARS-CoV-2 Nsp6 protein with high significance, which indicates SLC6A15 as a potential therapeutic target.
• Reactome Pathway:
  Na+/Cl- dependent neurotransmitter transporters (R-HSA-442660)
  Amino acid transport across the plasma membrane (R-HSA-352230)

The Drug Transporter (DTP) Role of This DTT

• DTT DTP Name: Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) DTP Info
• Gene Name: SLC6A15

References

• [1] A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing. Nature. 2020 Apr 30. doi: 10.1038/s41586-020-2286-9.