General Information of Drug Therapeutic Target (DTT) (ID: TT79JGK)

DTT Name Mycobacterium RNA polymerase (MycB RNAP)
Synonyms Transcriptase; RNAP; RNA polymerase; Mycobacterium DNA-directed RNA polymerase
Gene Name MycB rpoA
DTT Type
Successful target
[1]
UniProt ID
RPOA_MYCTU ; RPOB_MYCTU ; RPOC_MYCTU ; RPOZ_MYCTU
TTD ID
T30938
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRIDGVL
HEFTTVPGVKEDVTEIILNLKSLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHN
PGMHIATLNDKGKLEVELVVERGRGYVPAVQNRASGAEIGRIPVDSIYSPVLKVTYKVDA
TRVEQRTDFDKLILDVETKNSISPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAE
ADHIASFALPIDDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIK
LHQLGLSLKDSPPSFDPSEVAGYDVATGTWSTEGAYDEQDYAETEQL
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
KEGG Pathway
Purine metabolism (mtu00230 )
Pyrimidine metabolism (mtu00240 )
Metabolic pathways (mtu01100 )
RNA polymerase (mtu03020 )
Reactome Pathway
Antimicrobial action and antimicrobial resistance in Mtb (R-HSA-9639775 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifamycin DMEH3O7 Diarrhea ME05.1 Approved [1]
Favipiravir DMBZ27L Influenza virus infection 1E30-1E32 Registered [2]
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1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
TAS-106 DML97KB Head and neck cancer 2D42 Phase 2 [3]
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3 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
JTK-003 DMB0V5Y Hepatitis C virus infection 1E51.1 Discontinued in Phase 2 [4]
R-1479 DM9C6LN Hepatitis C virus infection 1E51.1 Discontinued in Phase 1 [5]
XTL-2125 DM3Y6M7 Hepatitis C virus infection 1E51.1 Discontinued in Phase 1 [6]
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References

1 Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4832-E4840.
2 Favipiravir (T-705), a novel viral RNA polymerase inhibitor.Antiviral Res.2013 Nov;100(2):446-54.
3 Phase I and pharmacokinetic study of 3'-C-ethynylcytidine (TAS-106), an inhibitor of RNA polymerase I, II and III,in patients with advanced solid malignancies.Invest New Drugs.2012 Feb;30(1):316-26.
4 Antiviral Therapy for Hepatitis C Virus: Beyond the Standard of Care. Viruses. 2010 April; 2(4): 826-866.
5 The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cel... J Biol Chem. 2006 Feb 17;281(7):3793-9.
6 DOI: 10.1111/j.1365-2036.2009.03927.x