Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT7UY6K)

DTT Name Glutamate decarboxylase 2 (GAD2)
Synonyms Glutamate decarboxylase 65 kDa isoform; GAD65; GAD2; 65 kDa glutamic acid decarboxylase
Gene Name GAD2
DTT Type
Clinical trial target
 [1]
BioChemical Class
Carbon-carbon lyase
UniProt ID
DCE2_HUMAN
TTD ID
T22128
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 4.1.1.15
Sequence
MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGG
SQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQ
YVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFN
QLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFS
PGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVI
LIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIW
MHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ
MHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEY
LYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEY
GTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL
Function Catalyzes the production of GABA.
KEGG Pathway
Alanine, aspartate and glutamate metabolism (hsa00250 )
beta-Alanine metabolism (hsa00410 )
Taurine and hypotaurine metabolism (hsa00430 )
Butanoate metabolism (hsa00650 )
Metabolic pathways (hsa01100 )
GABAergic synapse (hsa04727 )
Type I diabetes mellitus (hsa04940 )
Reactome Pathway
GABA synthesis, release, reuptake and degradation (R-HSA-888590 )
MECP2 regulates transcription of genes involved in GABA signaling (R-HSA-9022927 )
GABA synthesis (R-HSA-888568 )
BioCyc Pathway
MetaCyc:HS06208-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diamyd DMOUGX1 Type-1 diabetes 5A10 Phase 3 [1]
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1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
s-allylglycine DMUPCA6 Discovery agent N.A. Investigative [2]
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References

1 Clinical pipeline report, company report or official report of Diamyd Medical.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1273).