Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT7X02I)

• DTT Name: Solute carrier family 26 member 4 (SLC26A4)
• Synonyms: Sodium-independent chloride/iodide transporter; SLC26A4
• Gene Name: SLC26A4
• DTT Type: Literature-reported target; [1]
• BioChemical Class: Sulfate permease
• UniProt ID: S26A4_HUMAN
• TTD ID: T77099
• Sequence:
  MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKR
  AFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSA
  FFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAA
  RDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVL
  NVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPI
  PIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVA
  YAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKT
  QVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAV
  IWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIE
  EPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRAT
  KNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVL
  DCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFL
  TVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS
• Function: Sodium-independent transporter of chloride and iodide.
• KEGG Pathway: Thyroid hormone synthesis (hsa04918)
• Reactome Pathway:
  Defective SLC26A4 causes Pendred syndrome (PDS) (R-HSA-5619046)
  Multifunctional anion exchangers (R-HSA-427601)

The Drug Transporter (DTP) Role of This DTT

• DTT DTP Name: Sodium-independent chloride/iodide transporter (SLC26A4) DTP Info
• Gene Name: SLC26A4

References

• [1] Role of pendrin in the pathophysiology of aldosterone-induced hypertension. Am J Hypertens. 2019 Apr 15. pii: hpz054.