Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT8WCXO)

DTT Name Bacterial NH(3)-dependent NAD(+) synthetase (Bact nadE)
Synonyms
efg; Nitrogen-regulatory protein; Nicotinamide adenine dinucleotide synthetase; NadE; NAD+ synthetase; NAD+ synthase; NAD(+)-synthetase; NAD synthetase; NAD synthase; Diphosphopyridine nucleotide synthetase
Gene Name Bact nadE
DTT Type
Literature-reported target
 [1]
BioChemical Class
Carbon-nitrogen ligase
UniProt ID
NADE_ECOLI
TTD ID
T86152
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTLQQQIIKALGAKPQINAEEEIRRSVDFLKSYLQTYPFIKSLVLGISGGQDSTLAGKLC
QMAINELRLETGNESLQFIAVRLPYGVQADEQDCQDAIAFIQPDRVLTVNIKGAVLASEQ
ALREAGIELSDFVRGNEKARERMKAQYSIAGMTSGVVVGTDHAAEAITGFFTKYGDGGTD
INPLYRLNKRQGKQLLAALACPEHLYKKAPTADLEDDRPSLPDEVALGVTYDNIDDYLEG
KNVPQQVARTIENWYLKTEHKRRPPITVFDDFWKK
Function Catalyzes a keystep in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction.
KEGG Pathway
Nicotinate and nicotinamide metabolism (ecj00760 )
Metabolic pathways (ecj01100 )
Biosynthesis of cofactors (ecj01240 )
BioCyc Pathway
MetaCyc:NAD-SYNTH-MON
EcoCyc:NAD-SYNTH-MON

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
4 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diphosphate DMHY30B Discovery agent N.A. Investigative [2]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [2]
Pyrophosphate 2- DMZQ75M Discovery agent N.A. Investigative [1]
[3H]alphabeta-meATP DMWV5C3 Discovery agent N.A. Investigative [2]
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References

1 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.