General Information of Drug Therapeutic Target (DTT) (ID: TT9B4N3)

DTT Name Prostaglandin receptor (PTGR)
Gene Name PTGR
DTT Type
Successful target
[1]
UniProt ID
NOUNIPROTAC
TTD ID
T47077

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
2 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bimatoprost DMX0E5B Alopecia ED70 Approved [2]
Unoprostone DMXNR04 Glaucoma/ocular hypertension 9C61 Approved [1]
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2 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Iclaprim DM7YNV9 Bacterial infection 1A00-1C4Z Phase 3 [3]
JB991 DMKU6MW Skin infection 1F28-1G0Z Phase 2 [4]
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5 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Taprostene DMA4WY5 Thrombosis DB61-GB90 Discontinued in Phase 3 [5]
TEI-6122 DM3F5E0 Diabetic complication 5A2Y Discontinued in Phase 2 [6]
ZD-4953 DM5UCHW Pain MG30-MG3Z Discontinued in Phase 2 [7]
YP-008 DM2N76V Psoriasis vulgaris EA90 Terminated [8]
YP-009 DMPXLG2 Solid tumour/cancer 2A00-2F9Z Terminated [9]
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1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
IP-1200 DMIX7CP Erectile dysfunction HA01.1 Investigative [10]
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References

1 Comparison of the vasoactive effects of the docosanoid unoprostone and selected prostanoids on isolated perfused retinal arterioles. Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1499-504.
2 Bimatoprost-induced calcium signaling in human T-cells does not involve prostanoid FP or TP receptors. Curr Eye Res. 2009 Mar;34(3):184-95.
3 Novel ocular antihypertensive compounds in clinical trials. Clin Ophthalmol. 2011; 5: 667-677.
4 US patent application no. 2006,0041,016, Composition and method for the treatment of psoriasis.
5 Partial agonism of taprostene at prostanoid IP receptors in vascular preparations from guinea-pig, rat, and mouse. J Cardiovasc Pharmacol. 2004 Jun;43(6):795-807.
6 The effect of a synthetic 7-thiaprostaglandin E1 derivative, TEI-6122, on monocyte chemoattractant protein-1 induced chemotaxis in THP-1 cells.. Br J Pharmacol. 1995 October; 116(4): 2298-2302.
7 WO patent application no. 2013,1675,82, Methods and pharmaceutical compositions for prevention or treatment of chronic obstructive pulmonary disease.
8 CA patent application no. 841416, Method of selecting therapeutic indications.
9 YP 009 York Pharma pc preclinical, UK(cancer), R & D Focus Drug News, November 12, 2007
10 Clinical pipeline report, company report or official report of Immunologic.