Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTAL6S1)

• DTT Name: F-box-like/WD repeat-containing protein TBL1X (TBL1X)
• Synonyms: SMAP55; Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linked
• Gene Name: TBL1X
• DTT Type: Clinical trial target; [1]
• UniProt ID: TBL1X_HUMAN
• TTD ID: T63187
• Sequence:
  MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVN
  FLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINED
  GTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSA
  GVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAW
  NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG
  TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT
  GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW
  DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS
  ASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV
  HSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
• Function: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272). {ECO:0000269|PubMed:14980219, ECO:0000269|PubMed:21240272}.
• KEGG Pathway: 6907 (hsa)
• Reactome Pathway:
  (R-HSA-1368082)
  (R-HSA-1368108)
  (R-HSA-1989781)
  (R-HSA-2122947)
  (R-HSA-2151201)
  (R-HSA-2426168)
  (R-HSA-2644606)
  (R-HSA-2894862)
  (R-HSA-3214815)
  (R-HSA-350054)
  (R-HSA-381340)
  (R-HSA-400206)
  (R-HSA-400253)
  (R-HSA-9022537)
  (R-HSA-9022692)
  (R-HSA-9029569)
  (R-HSA-9609690)
  (R-HSA-9707564)
  (R-HSA-9707616)

Molecular Interaction Atlas (MIA) of This DTT

2 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SY-2101	DMRHJOO	Acute promyelocytic leukaemia	2A60.0	Phase 1	[1]
Tegavivint	DMPJ3YX	Desmoid tumour	2F7C	Phase 1	[2]

References

• [1] Transducin beta-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma. Haematologica. 2021 Nov 1;106(11):2927-2939.
• [2] Tegavivint and the beta-Catenin/ALDH Axis in Chemotherapy-Resistant and Metastatic Osteosarcoma. J Natl Cancer Inst. 2019 Nov 1;111(11):1216-1227.